Absolute configuration of pterocidin,a potent inhibitor of tumor cell invasion from a marine-derived Streptomyces |
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| Authors: | Yasuhiro Igarashi Daisuke Asano Kazuo Furihata Naoya Oku Satoshi Miyanaga Hiroaki Sakurai Ikuo Saiki |
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| Affiliation: | 1. Biotechnology Research Center, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan;2. Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan;3. Department of Bioscience, Institute of Natural Medicine, Toyama University, 2630 Sugitani, Toyama 930-0194, Japan |
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| Abstract: | ![]()
During the course of screening natural products for the inhibitors of tumor cell invasion, pterocidin, a linear polyketide with a δ-lactone terminus, was rediscovered from a Streptomyces strain of a marine sediment-origin. A series of J-based configuration analyses and NOESY analysis, coupled with chemical derivatization and chiral anisotropy analysis, established the absolute stereochemistry of five asymmetric centers in this compound. |
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