摘 要: | A new method to synthesize a degradable terminal amino group-containing copolymer,poly(ethylene glycol)-b- poly(ε-caprolactone)(MPEG-PCL-NH_2),was developed in the following three steps:(1)the ring-opening polymerization (ROP)ofε-caprolactone from the Schiff base prepared from benzatdehyde and ethanolamine(Ph-CH=NCH_2CH_2OH)used as an initiator to obtain heterobifunctional poly(ε-caprolactone)with one terminal Schiff base group and one hydroxyl group (HO-PCL-CH_2CH_2N=CH-Ph);(2)the coupling reaction of two reactive precursors,a hydroxy-terminated HO-PCL- CH_2CH_2N=CH-Ph andα-monocarboxy-ω-monomethoxy poly(ethylene glycol)(CMPEG)to synthesize MPEG-PCL- CH_2CH_2N=CH-Ph;(3)the conversion of the -N=CH-Ph end-group into NH_2 end-group by acidification of acetic acid to obtain MPEG-PCL-NH_2.The structures from the precursors to the terminal amino group-containing copolymer were confirmed by ~1H-NMR and their molecular weights were measured by gel permeation chromatography.The amphiphilic terminal amino group-containing copolymer could self-assemble into micelles in an aqueous system with PCL block as the core and PEG block as the shell.The micelle formation of the terminal amino group-containing block copolymer was studied by fluorescent probe technique and the existence of critical micellar concentration(cmc)confirmed the amphiphilic nature of the resulting copolymer.ESEM and DLS analysis of the micelles revealed a homogeneous spherical morphology and a unimodal size distribution.
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