| Synthesis,Structure and Antimicrobial Activity of 2-Phenyl-4H-spiro[benzo[e][1,4,2]oxaza- phosphinine-3,3′-indolin]-2′-one 2-oxide |
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| 引用本文： | 刘仁蝶,孔杜林,吴明书,李高楠,李国柱.Synthesis,Structure and Antimicrobial Activity of 2-Phenyl-4H-spiro[benzo[e][1,4,2]oxaza- phosphinine-3,3′-indolin]-2′-one 2-oxide[J].结构化学,2014(2):204-208. |
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| 作者姓名： | 刘仁蝶 孔杜林 吴明书 李高楠 李国柱 |
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| 作者单位： | [1]Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of Education, College of Chemistry ＆ Chemical Engineering, Hainan Normal University, Haikou 571158, China [2]School of Pharmaceutical Sciences, Haman Medical University, Haikou 571199, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China （No. 21162008） |
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| 摘 要： | A novel spiro-compound(C20 H15 N2 O3 P) has been synthesized and characterized by means of IR and 1H NMR. Its crystal structure was determined by X-ray diffractometry. The crystal belongs to the monoclinic system, space group P21 /c with a = 9.1628(7), b = 12.9490(7), c = 15.7898(11), β = 103.952(8)o, Mr = 36.08, V = 1818.2(2)3, Z = 4, Dc = 1.382 g/cm3, F(000) = 788, μ = 0.179 mm-1, R = 0.0701 and wR = 0.1513. The preliminary biological test showed that the title compound has activities against Escherichia coli, S.albus, Bacillus subtilis, Staphylocc- ocusaureus and Micrococcus tetragenus with MIC to be 0.038, 0.038, 0.075, 2.48, and 0.15 mg/mL, respectively.
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| 关 键 词： | 螺环化合物 晶体结构 抗菌活性 合成 苯基 吲哚 二氢 氧化 |
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