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Stepwise Self-assembly of a Tripeptide from Molecular Dimers to Supramolecular β-sheets in Crystals and Amyloid-like Fibrils in the Solid State |
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| Authors: | Apurba Kumar Das Michael GB Drew Debasish Haldar Arindam Banerjee |
| Institution: | 1. Department of Biological Chemistry , Indian Association for the Cultivation of Science , Jadavpur, Kolkata, 700 032, India;2. Department of Chemistry , The University of Reading , Whiteknights, Reading, RG6 6AD, UK |
| Abstract: | The terminally protected tripeptide Boc–Ala(1)–Leu(2)–Ala(3)–OMe 1 forms antiparallel hydrogen-bonded dimers of two different conformers in the asymmetric unit and the individual dimers then self-associate to form supramolecular β-sheet structures in crystals and amyloid-like fibrils in the solid state. |
| Keywords: | Self-assembly Molecular dimer Peptide Amyloid-like fibrils |