N-[2-(4-Methoxy-phenyl)-ethyl]-2-(quinolin-8-yloxy)acetamide: a receptor for acid binding |
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Authors: | Anirban Karmakar |
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Institution: | Department of Chemistry , Indian Institute of Technology Guwahati , Guwahati, Assam, India |
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Abstract: | Different hydrates of the receptor, N-2-(4-methoxy-phenyl)-ethyl]-2-(quinolin-8-yloxy)acetamide (I), and its co-crystals with acetic acid and l(+)α-hydroxy-phenylacetic acid are synthesised and their structures are studied. The acids such as acetic acid, l(+)α-hydroxy-phenylacetic acid quench fluorescence of I. The receptor I shows a fluorescence quenching on interaction with perchloric acid in benzene, whereas in methanol the solution of I results in the generation of a new fluorescence emission at higher wavelengths. The crystal structure of the perchlorate salt is determined to explain the protonation behaviour of the receptor I and the perchlorate salt in methanol leads to fluorescence emission at a place different from that of the parent compound. |
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Keywords: | amide receptor acid binding fluorescence quenching 8-hydroxyquinoline derivative psuedo-polymorph |
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