|
|||||
|
|
Nonlinear Dependence of Fish Bioconcentration on n-Octanol/Water Partition Coefficient |
|
| Authors: | S Bintein J Devillers W Karcher |
| Institution: | 1. CTIS , 21 rue de la Bannière, 69003, Lyon, France;2. Commission of the European Communities, Joint Research Centre, ISPRA Establishment , I-21020, Ispra Varese, Italy |
| Abstract: | Abstract The log-log relationship between the bioconcentration tendency of organic chemicals in fish and the n?octanol/water partition coefficients breaks down for very hydrophobic compounds. The use of parabolic and bilinear models allows this problem to be overcome. The QSAR equation log BCF = 0.910 log P - 1.975 log (6.8 10?7 P + 1) - 0.786 (n = 154; r = 0.950; s = 0.347; F = 463.51) was found to be a good predictor of bioconcentration in fish. |
| Keywords: | Bioconcentration BCF fish bilinear model linear model parabolic model |