Artificial periosteum in bone defect repair——A review

We review the development of artifi cial periosteum and classify it into three approaches based on the material source, that is, native tissues, scaffoldfree cell sheets and scaffold-cell composites. Mechanisms, methods and effi cacy of each approach are provided. Existing obstacles and enabling technologies for future directions are also discussed.

Artificial periosteum in bone defect repair-A review

Periosteum is a thin membrane that encases the surfaces of most bones. It is composed of an outer fibrous layer contains longitudinally oriented cells and collagen fibers and an inner cambial layer that consists of multipotent mesenchymal stem cells (MSCs) and osteogenic progenitor cells. Periosteum has a function of regulating cell and collagen arrangement, which is important to the integrity, modelling and remodelling of bone, particularly during bone defect repair. Apart from autograft and allograft, artificial periosteum, or tissue-engineered periosteum mimicking native periosteum in structure or function, made up of small intestinal submucosa, acellular dermis, induced membrane, cell sheets, and polymeric scaffolds, and so on, has been developed to be used in bone defect repair. In this review, we classify the artificial periosteum into three approaches based on the material source, that is, native tissues, scaffoldfree cell sheets and scaffold-cell composites. Mechanisms, methods and efficacy of each approach are provided. Existing obstacles and enabling technologies for future directions are also discussed.