Development of a modified beta-cyclodextrin based fluorosensor for dipyridamole |
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| Authors: | Zhilong Gong and Zhujun Zhang |
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| Affiliation: | (1) Department of Chemistry, Nanjing University, Nanjing 210093, China, CN;(2) Department of Chemistry, Shaanxi Normal University, Xi’an 710062, China, CN |
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| Abstract: | 2,6-O-diethyl-β-cyclodextrins were prepared and immobilized onto silica gel to develop a fluorosensor for dipyridamole. The analytical performance characteristics of the proposed sensor for analysis of dipyridamole were as follows: the detection limit was 0.8 nmol/L with a relative standard deviation of 1.4% for 10 determinations of 50 nmol/L of dipyridamole. The modification of β-CD improved the sensitivity and selectivity for measuring dipyridamole. The recommended method has been successfully tested for the determination of dipyridamole in clinical samples (urine and pharmaceutical preparations). Received: 23 January 1997 / Revised: 14 April 1997 / Accepted: 21 April 1997 |
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