Indium bromide catalysed, ultrasound-assisted, regio-selective synthesis of ethyl-5-(trifluoromethyl)-1-(3-substituted-isoquinolin-1-yl)-1H-pyrazole-4-carboxylates |
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| Authors: | K Prabakaran F Nawaz Khan Jong Sung Jin P Manivel |
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| Institution: | 1. Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632 014, Tamil Nadu, India
2. Division of High Technology Materials Research, Busan Center, Korea Basic Science Institute (KBSI), Busan, 618 230, Korea
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| Abstract: | A series of pyrazole-4-carboxylates have been synthesised using indium bromide catalyst and the cyclisation of respective 3-substituted-isoquinolinylhydrazines 1 into their corresponding ethyl-2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoates 3 in ethanol solvent under ultrasonic irradiation at 90?°C for 30 min. The regio-selective cyclisation products were efficiently provided by indium bromide catalyst and are confirmed by nuclear Overhauser effect spectroscopy?Cnuclear magnetic resonance (NOESY?CNMR) studies. |
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