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| Polystyrene-supported Selenides and Selenoxide: Versatile Routes to Synthesize Allylic Alcohols | |
| 引用本文： | Wei Ming XU1,You Chu ZHANG2,Xian HUANG1* 1Department of Chemistry,Zhejiang University (Xixi Campus),Hangzhou 310028 2Department of Chemistry,Shaoxing College of Arts and Sciences,Shaoxing 312000. Polystyrene-supported Selenides and Selenoxide: Versatile Routes to Synthesize Allylic Alcohols[J]. 中国化学快报, 2003, 14(8) |
| 作者姓名： | Wei Ming XU1 You Chu ZHANG2 Xian HUANG1* 1Department of Chemistry Zhejiang University (Xixi Campus) Hangzhou 310028 2Department of Chemistry Shaoxing College of Arts and Sciences Shaoxing 312000 |
| 作者单位： | Wei Ming XU,Xian HUANG(Department of Chemistry, Zhejiang University(Xixi Campus), Hangzhou 310028);You Chu ZHANG(Department of Chemistry, Shaoxing College of Arts and Sciences, Shaoxing 312000) |
| 摘 要： | Combinatorial chemistry and solid phase synthesis have recently emerged as powerful tools for the drug discovery process1. It might be argued that selenoxide syn- elimination provided the principal impetus for the development of organoselenium chemistry. [2, 3] Sigmatropic rearrangement2 of allylic selenium compounds is the most fundamental reaction in the field of synthetic organoselenium chemistry as well as selenoxide syn-elimination. However, organic selenides are highly malodorous and … |
Polystyrene-supported Selenides and Selenoxide:Versatile Routes to Synthesize Allylic Alcohols |
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| Wei Ming XU,You Chu ZHANG,Xian HUANG. Polystyrene-supported Selenides and Selenoxide:Versatile Routes to Synthesize Allylic Alcohols[J]. Chinese Chemical Letters, 2003, 14(8) | |
| Authors: | Wei Ming XU You Chu ZHANG Xian HUANG |
| Affiliation: | Xixi Campus |
| Abstract: | Several polystyrene-supported selenides and selenoxide have been prepared firstly. These novel reagents were treated with LDA to produce selenium stabilized carbanions, which reacted with aldehydes and alkyl halides, followed by selenoxide syn-elimination and [2,3] sigmatropic rearrangement respectively to give Z-allylic alcohols stereoselectively. |
| Keywords: | Solid phase synthesis selenides and selenoxide allylic alcohol. |
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