O‐2′,3′‐Ketal‐Nucleolipids of the Cytostatic 5‐Fluorouridine: Synthesis,Lipophilicity, and Acidic Stability |
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Authors: | Edith Malecki Helmut Rosemeyer |
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Abstract: | The synthesis of a series of cyclic and acyclic O‐2′,3′‐ketal derivatives of the cancerostatic 5‐fluorouridine ( 2a ) is described. The novel compounds were characterized by 1H‐ and 13C‐NMR, and UV spectroscopy, as well as by elemental analyses. The lipophilicity values (log P, retention times in RP‐18 HPLC) of the cyclic ketals were determined and related to the ring tensions as well as the acid stability of the spiro‐linked ketal rings. |
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Keywords: | Nucleolipids 5‐Fluorouridine β ‐D‐Ribonucleosides Nucleosides Lipophilicity |
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