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New Sphingolipids and Other Constituents of Pancovia laurentii
Authors:Ferdinand Tantangmo  Bruno Ndjakou Lenta  Silvre Ngouela  Louis Marie Kamdem  Bernard Weniger  Etienne Tsamo  Annelise Lobstein  Catherine Vonthron‐Sncheau
Abstract:Phytochemical investigation of the bark and leaves of Pancovia laurentii (Sapindaceae) resulted in the isolation of a new ceramide and a new cerebroside, named pancoviamide ( 1 ), and pancovioside ( 2 ) respectively, together with six known compounds: uracil, (R)‐N‐(1S,2S,3R)‐2,3‐dihydroxy‐1‐(hydroxymethyl)heptadec‐5‐en‐1‐yl]‐2‐hydroxytetracosanamide, stigmasta‐7,22‐dien‐3‐ol, β‐stitosterol, β‐sitosterol 3‐O‐β‐D ‐glucopyranoside, and 2,3‐dihydroxypropyl pentadecanoate. The structures of 1 and 2 were determined by means of spectroscopic methods. Compounds 1 and 2 were tested in vitro for their antiprotozoal properties against several protozoa and for their cytotoxicity.
Keywords:Pancovia laurentii  Sphingolipids  Pancoviamide  Pancovioside  Antiprotozoal activity  Cytotoxic activity
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