| 温度敏感的PLGA-PEG-PLGA水凝胶的合成、 表征和药物释放 |
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| 引用本文： | 林浩,田华雨,孙敬茹,庄秀丽,陈学思,李悦生,景遐斌.温度敏感的PLGA-PEG-PLGA水凝胶的合成、 表征和药物释放[J].高等学校化学学报,2006,27(7):1385-1388. |
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| 作者姓名： | 林浩 田华雨 孙敬茹 庄秀丽 陈学思 李悦生 景遐斌 |
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| 作者单位： | 1. 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春,130022;中国科学院研究生院,北京,100039
2. 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春,130022 |
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| 基金项目： | 国家自然科学基金(批准号:50573078,50273038)，国家自然科学杰出青年基金(批准号:50425309)资助 |
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| 摘 要： | 用聚乙二醇PEG1000和4600引发乙交酯(GA)和L-丙交酯(L-LA)开环共聚合得到一系列数均分子量为3000~7000的PLGA-PEG-PLGA水凝胶材料. 综合应用动态粘弹谱仪和相图, 系统报道了该凝胶力学性质和溶胶-凝胶转变的关系, 凝胶区间的模量在102~104 Pa之间. 用荧光光谱证明了该三嵌段聚合物形成胶束的性质并测定了临界胶束浓度, 验证了凝胶由胶束形成的机理. 凝胶中的头孢他定释放呈现一定程度的缓释作用.
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| 关 键 词： | 聚乙二醇 乙交酯-丙交酯共聚物 水凝胶 温度敏感 力学性质 药物释放 |
| 文章编号： | 0251-0790（2006）07-1385-04 |
| 收稿时间： | 10 19 2005 12:00AM |
| 修稿时间： | 2005-10-19 |
Synthesis, Characterization and Drug Release of Temperature-sensitive PLGA-PEG-PLGA Hydrogel |
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| LIN Hao,TIAN Hua-Yu,SUN Jing-Ru,ZHUANG Xiu-Li,CHEN Xue-Si,LI Yue-Sheng,JING Xia-Bin.Synthesis, Characterization and Drug Release of Temperature-sensitive PLGA-PEG-PLGA Hydrogel[J].Chemical Research In Chinese Universities,2006,27(7):1385-1388. |
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| Authors: | LIN Hao TIAN Hua-Yu SUN Jing-Ru ZHUANG Xiu-Li CHEN Xue-Si LI Yue-Sheng JING Xia-Bin |
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| Institution: | 1. State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China ; 2. Graduate School of Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | A series of PLGA-PEG-PLGAs with Mn=3000—7000 were synthesized by ROP of L-lactide and glycolide with PEG(Mw=1000 and 4600) as the initiators. The dynamic viscoanalyser and phase diagram were utilized to investigate the mechanical properties with sol-gel transition of the hydrogel system, and the G' and G″were between 102 and 104 Pa. Also, the fluorescence spectroscopy of PLGA-PEG-PLGA micelle solution was investigated to reveal the gelation mechanism of hydrogel. Finally, the controlled release of ceftazidime from the hydrogel was observed. |
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| Keywords: | PEG PLGA Hydrogel Temperature-sensitivity Mechanical property Drug release |
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