Tin (IV) chloride-promoted one-pot synthesis of novel tacrine analogues |
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| Authors: | Hu Huanan Song Liangfu Fang Qianqian Zheng Junjun Meng Zhiwei Luo Yiting |
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| Institution: | College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China. hhn12192000@yahoo.com.cn |
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| Abstract: | A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, 1H- and 13C-NMR. |
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