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排序方式: 共有275条查询结果,搜索用时 15 毫秒
1.
Ai-hua Zhang Zhi-ming Ma Ling Kong Hong-lei Gao Hui Sun Xiang-qian Wang Jing-bo Yu Ying Han Guang-li Yan Xi-jun Wang 《Biomedical chromatography : BMC》2020,34(2):e4724
Lipid metabolism has a significant function in the central nervous system and Alzheimer's disease (AD) is an age-related senile disease characterized by central nerve degeneration. The pathological development of AD is closely related to lipid metabolism disorders. To reveal the influence of Kai-Xin-San (KXS) on lipid metabolism in APP/PSI transgenic mice and potential therapeutic targets for treating AD, brain tissue samples were collected and analyzed by high-throughput lipidomics based on UPLC–Q/TOF-MS. The collected raw data were processed by multivariate data analysis to discover the potential biomarkers and lipid metabolic profiles. Compared with the control wild-type mouse group, nine potential lipid biomarkers were found in the AD model group, of which seven were up-regulated and two were down-regulated. Orally administrated KXS can reverse the changes in these potential biomarkers. Compared with the model group, a total of six differential metabolites showed a recovery trend and may be potential targets for KXS to treat AD. This study showed that high-throughput lipidomics can be used to discover the perturbed pathways and lipid biomarkers as potential targets to reveal the therapeutic effects of KXS. 相似文献
2.
Yulin Ren Sijin Wu Joanna E. Burdette Xiaolin Cheng A. Douglas Kinghorn 《Molecules (Basel, Switzerland)》2021,26(12)
Digoxin is a cardiac glycoside long used to treat congestive heart failure and found recently to show antitumor potential. The hydroxy groups connected at the C-12, C-14, and C-3′a positions; the C-17 unsaturated lactone unit; the conformation of the steroid core; and the C-3 saccharide moiety have been demonstrated as being important for digoxin’s cytotoxicity and interactions with Na+/K+-ATPase. The docking profiles for digoxin and several derivatives and Na+/K+-ATPase were investigated; an additional small Asn130 side pocket was revealed, which could be useful in the design of novel digoxin-like antitumor agents. In addition, the docking scores for digoxin and its derivatives were found to correlate with their cytotoxicity, indicating a potential use of these values in the prediction of the cancer cell cytotoxicity of other cardiac glycosides. Moreover, in these docking studies, digoxin was found to bind to FIH-1 and NF-κB but not HDAC, IAP, and PI3K, suggesting that this cardiac glycoside directly targets FIH-1, Na+/K+-ATPase, and NF-κB to mediate its antitumor potential. Differentially, digoxigenin, the aglycon of digoxin, binds to HDAC and PI3K, but not FIH-1, IAP, Na+/K+-ATPase, and NF-κB, indicating that this compound may target tumor autophagy and metabolism to mediate its antitumor propensity. 相似文献
3.
Using chemical separations and radiometric measurements medium-half-life irradiation products of molybdenum with 12.5 MeV deuterons were determined (90Nb, 92Nb, 95mNb, 95Nb, 96Nb, 99Mo, 95mTc, 96Tc, 99mTc) as well as thick target yields for some of them: 92Nb (0.22 μCi/μAh), 95Nb(0.05 μCi/μAh), 99Mo (64 μCi/μAh), 95mTc(0.76 μCi/μAh), 96Tc((62.5 μCi/μAh). Moreover isolation possibiities of radioactive preparations from removed worn-cut molybdenum parts of the U-120 cycletron are discussed. 相似文献
4.
In this paper we study the profitability of car manufacturers in relation to industry-wide profitability targets such as industry averages. Specifically we are interested in whether firms adjust their profitability in the direction of these targets, whether it is possible to detect any such change, and, if so, what the precise nature is of these changes. 相似文献
5.
В. П. Бочսռ 《Isotopes in environmental and health studies》2013,49(8):317-321
A non-contact measuring method on electrostatic potential by using α-ray ionization is proposed. In this method potential of a charged material is estimated from ionic current flowing through an ion collector attached with a small 241Am source. As hade electrode surrounding the collector has a function of adjusting sensitivity and potential up to 50 kV was measured with precision of 1 kV. 相似文献
6.
Abstract By combination of energy and time of flight detection in ERDA or NRA measurement, the particles' masses can be determined, additionally to the depth information. This leads to unique depth profile determination even for complex targets. Combination with th concept of Jacobi transformations results in extremely fast measurements. In this paper, a way is shown how this concept can be realized even for accelerators ofenergies as low as about 1 MeV. 相似文献
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8.
橡胶基复合靶抗贯穿特性的近似分析方法 总被引:2,自引:0,他引:2
采用体积含量加权的方法确定了复合靶等效状态方程参数,采用纤维含量平方外推的方法确定了复合靶的等效强度。然后利用球腔膨胀和柱腔贯穿相结合的方法提出了一种分析计算钢球贯穿橡胶基复合靶的近似分析模型。计算方法简明、高效,而且对剩余速度和临界穿透速度等的计算结果与已有实验有良好的符合。 相似文献
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10.
截卵形弹头对混凝土靶侵彻性能的试验研究 总被引:6,自引:0,他引:6
介绍了截卵形弹头钻地弹对混凝土靶的侵彻试验研究结果。根据缩比钻地弹侵彻过程的高速录像和试验结果对弹丸运动状态进行了分析,得出了截卵形弹头钻地弹侵彻混凝土靶的速度变化曲线和阻力变化曲线;利用缩比理论,给出了标准钻地弹对混凝土靶侵彻性能的计算方法和分析结果。 相似文献