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1.
Synthesis,Characterisation and Crystal Structures of Two Bi‐oxadiazole Derivatives Featuring the Trifluoromethyl Group 下载免费PDF全文
Marcos A. Kettner Prof. Dr. Thomas M. Klapötke Tomasz G. Witkowski Felix von Hundling 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(11):4238-4241
The synthesis, characterisation, and crystal structure determination of the closely related compounds 3,3′‐bi‐(5‐trifluoromethyl‐1,2,4‐oxadiazole) and 5,5′‐bi‐(2‐ trifluoromethyl‐1,3,4‐oxadiazole) are reported. These two compounds are known for their bioactivity; however, in this study they serve as model compounds to evaluate the suitability of the heterocyclic oxadiazole ring system for energetic materials when the fluorine atoms in the exocyclic CF3 groups are substituted successively by nitro groups. Quantum chemical calculations for the bi‐1,3,4‐ oxadiazole derivatives with difluoronitromethyl, fluorodinitromethyl, and trinitromethyl groups have been carried out and predict promising energetic performances for both explosive and propulsive applications. 相似文献
2.
Mihály V. Pilipecz Tamás R. Varga Péter Králl Zoltán Vincze Zoltán Mucsi Ruth Deme 《合成通讯》2020,50(11):1712-1723
AbstractThe novel push–pull alkene, the 2-(nitro-nitrosomethylene)-pyrrolidine with numerous aliphatic or aromatic amines as nucleophiles afforded amidoximes. Various substituted oxadiazaborole and oxadiazole derivatives were prepared starting from these amidoximes, widening the synthetic applicability of the push–pull alkenes. Acylation of the amidoximes was also examined. The mechanism of the amidoxime formation was investigated by computational methods. 相似文献
3.
A series of substituted 1,3,4‐oxadiazole, 1,2,4‐triazole, and 1,3,4‐thiadiazole derivatives of the substituted 3‐carboethoxy‐1,4‐dihydro‐4‐oxoquinoline have been synthesized through the reaction of the key intermediate thiosemicarbazide derivatives with different reagents. N′‐Arylidene‐4‐oxo‐1,4‐dihydroquinoline‐3‐carbohydrazides were also synthesized through the condensation reaction of the corresponding hydrazides with the appropriate aldehydes. Antimicrobial activity of some of the synthesized compounds was evaluated. 相似文献
4.
The synthesis of new 1,2,4‐ and 1,3,4‐oxadiazole derivatives as potential nonpeptide angiotensin II receptor antagonists is described. The quinoxalinone systems used as the “northern moiety” in these compounds were alkylated through a liquid/liquid phase‐transfer catalysis protocol, with good yields and high nitrogen‐ to oxygen‐alkylated product (N/O) ratios. 相似文献
5.
Marcos A. Kettner Prof. Dr. Konstantin Karaghiosoff Prof. Dr. Thomas M. Klapötke Dr. Muhamed Sućeska Swetlana Wunder 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(25):7622-7631
Here we report on the preparation of two hydrogen atom free 3,3′‐bi(1,2,4‐oxadiazole) derivatives. 5,5′‐Bis(fluorodinitromethyl)‐3,3′‐bi(1,2,4‐oxadiazole) was synthesised by fluorination of diammonium 5,5′‐bis(dinitromethanide)‐3,3′‐bi(1,2,4‐oxadiazole). For our previously reported analogue 5,5′‐bis(trinitromethyl)‐3,3′‐bi(1,2,4‐oxadiazole), a new synthetic route starting from new 3,3′‐bi(1,2,4‐oxadiazolyl)‐5,5′‐diacetic acid was developed. In this course also hitherto unknown 5,5′‐dimethyl‐3,3′‐bi(1,2,4‐oxadiazole) was isolated. The compounds were characterised by multinuclear NMR spectroscopy, IR and Raman spectroscopy, elemental analysis as well as mass spectrometry. X‐ray diffraction studies were performed and the crystal structures for the 5,5'‐dimethyl and 5,5'‐(fluorodinitromethyl) derivatives are reported. The energetic 5,5'‐(fluorodinitromethyl) and 5,5'‐(trinitromethyl) compounds do not contain any hydrogen atoms and show remarkable high densities. Furthermore, the thermal stabilities and sensitivities were determined by differential scanning calorimetry (DSC) and standardised impact and friction tests. The heats of formation were calculated by the atomisation method based on CBS‐4M enthalpies. With these values and the room‐temperature X‐ray densities, several detonation and propulsion parameters, such as the detonation velocity and pressure as well as the specific impulse of mixtures with aluminium, were computed using the EXPLO5 code. 相似文献
6.
Irina O. Zhuravel Oleg V. Zaremba Oleksandr S. Detistov Svitlana S. Kovalenko Valentin P. Chernykh 《合成通讯》2013,43(21):3778-3784
New 5-hydroxymethyl-8-methyl-3-(3-aryl-[1,2,4]oxadiazol-5-yl)-2H-pyrano-[2,3-c]pyridin-2-ones and their esters were synthesized. The structure of obtained compounds was determined through a complete 1H NMR analysis. 相似文献
7.
Published data on the synthesis of azoles containing two pyridine substituents are analyzed in relation to the type of central
five-membered ring. The applications of such molecules as ligands in coordination chemistry are discussed.
Dedicated to Academician Nikolai Serafimovich Zefirov in honor of his seventieth birthday.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1290–1301, September, 2005. 相似文献
8.
W. Szczepankiewicz J. Suwinski Z. Karczmarzyk 《Chemistry of Heterocyclic Compounds》2004,40(6):801-806
The reaction of N-phenylbenzamidine with O-acetylbenzeneoximoyl chloride in methanol solution gave unexpectedly 5-methoxy-3,4,5-triphenyl-4,5-dihydro-1,2,4-oxadiazole, which structure was confirmed by X-ray analysis. The last step of this reaction was simulated by the PM3 semiempirical method. 相似文献
9.
液晶性噁二唑类载流子传输材料 总被引:1,自引:1,他引:0
将液晶基团引入到载流子传输材料中合成了新型液晶性噁二唑类衍生物E3和E6,利用偏光显微镜、差热扫描和广角X射线衍射的方法对其液晶性进行了研究,结果表明,E3为单向近晶型液晶,E6为双向近晶型液晶。同时,利用紫外—可见吸收光谱和电化学方法测定了材料的能级结构参数,其高的LUMO能级。低的HOMO能级(相对真空能级)及较大的带隙表明,它们不仅有利于电子从阴极的注入,还对空穴和激子具有一定的阻挡作用。由于材料在有序的近晶相比在无序的各向同性相将具有高的载流子迁移率,因此将液晶性与传输性相结合对提高材料载流子迁移率具有非常重要的意义。 相似文献
10.
微波作用下2,5-二取代-1,3,4-噁二唑的合成 总被引:2,自引:0,他引:2
2 ,5 二取代 1 ,3 ,4 二唑可用作药品 ,光敏物质 ,闪烁体 ,激光材料 ,高分子液晶单体等[1- 5] 。一种是以芳香酸与水合肼作为原料用多聚磷酸作为脱水环合剂来合成此类化合物[6 ] ,另一种是由芳香酸转变为芳香酰氯或酯 ,再与水合肼反应得到单酰肼或二酰肼 ,最后用三氯氧磷[7] ,五氧化二磷和五氯化磷[8] ,一氯三甲硅[9] 脱水环合 ;此外 ,用水合肼和尿素合成得到的氨基脲代替水合肼 ,与芳香酸缩合合成二唑[10 ] ,这些方法共同的缺陷是 :环合时间较长 ,少者 4~ 5h ,多则 8h。近年来 ,微波技术在有机合成及其杂环化合物的合成中得到了广… 相似文献