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Jeffrey J. Jackson Dr. Hiroyuki Kobayashi Sophia D. Steffens Prof. Dr. Armen Zakarian 《Angewandte Chemie (International ed. in English)》2015,54(34):9971-9975
The asymmetric synthesis of dragmacidin D ( 1 ) was completed in 10 steps. Its sole stereocenter was set by using direct asymmetric alkylation enabled by a C2‐symmetric tetramine and lithium N‐(trimethylsilyl)‐tert‐butylamide as the enolization reagent. A central Larock indole synthesis was employed in a convergent assembly of the heterocyclic subunits. The stereochemical evidence from this work strongly supports the predicted S configuration at the 6′′′ position, which is consistent with other members of the dragmacidin family of natural products. 相似文献
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