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Imipenem shows a fast chemical conversion to a more stable imin form (identical to that of biochemical dehydropeptidase degradation) in aqueous solutions and stabilizing agents used avoid its electrochemical study and determination.The aim of this work is the proposal of urea as stabilizing agent which allows the electrochemical study of imipenem and the proposal of electrochemical methods for the determination of imipenem and its primary metabolite (M1) in human urine samples. Electrochemical studies were realized in phosphate buffer solutions over pH range 1.5-8.0 using differential-pulse polarography, DC-tast polarography, cyclic voltammetry and adsorptive stripping voltammetry. In acidic media, a non-reversible diffusion-controlled reduction involving a two steps mechanism which involves one electron and one proton in the first step and two electrons and two protons in the second step occurs and the mechanism for the reduction was suggested.A differential-pulse polarographic method for the determination of imipenem in the concentration range 3.2 × 10−6 to 2 × 10−5 M (0.95-3.4 mg/L) and its primary metabolite in the concentration range 1.4 × 10−6 to 10−4 M (0.43-26.1 mg/L) with detection limits of 9.6 × 10−7 M (0.28 μg/L imipenem) and 4.3 × 10−7 M (0.14 μg/L M1) was proposed. Also, a method based on controlled adsorptive pre-concentration of imipenem on the hanging mercury drop electrode followed by voltammetric measure, allows imipenem determination in the concentration range 1.8 × 10−8 to 1.2 × 10−6 M (5.42-347 μg/L) with a detection limit of 5.4 × 10−9 M (1.63 μg/L). The proposed methods have been used for the direct determination of the analytes in a pharmaceutical formulation and human urine.  相似文献   
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在碱性条件下,亚胺培南对鲁米诺-K_3[Fe(CN)_6]化学发光体系具有增敏作用,据此,结合流动注射技术建立了一种测定亚胺培南的新方法。在最优的实验条件下,亚胺培南对化学发光的增敏强度与其浓度在4.0×10~(-8)~4.0×10~(-6) g/mL范围内呈现出良好的线性关系,检测限为1.1×10~(-8) g/mL,相对标准偏差为1.7%(n=11)。该方法可用于亚胺培南的测定,回收率为99.4%~101.8%。  相似文献   
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