Synthesis of polypyrrole nanoparticles and its grafting with silica gel for selective binding of chromium(VI)

Polypyrrole nanoparticles of desired structure have been synthesized through simple micelle technique. It is then grafted with functionalized silica gel to develop a novel organic-inorganic hybrid material. The role of dimethyl dichloro silane (coupling agent) in grafting is demonstrated. The nanoparticles are characterized by TEM, SEM and TGA. Grafting reactions are evaluated by spectral (FTIR) analysis and chemical test. The Cr(VI) binding behavior of the composite is studied in various pH of the medium. The selectivity in binding Cr(VI) is monitored. The metal ion adsorption capacity and surface area of the material are found to be 38 mg/g and 235 m²/g, respectively.     

高聚物基因载体的功能化研究

寻找安全、高效的基因载体是基因治疗的关键问题之一，聚合物基因载体具有低毒、低成本、可设计性强等优良的性质，是未来基因载体发展的方向。传统的高聚物作为基因载体时，功能单一，不能完全满足基因治疗的需要，因此对载体进行功能化修饰是十分必要的。本文在分析基因治疗过程的基础上，详述了基因载体应具有的四种基本功能——在细胞外保持稳定的功能、进入细胞的功能、逃离溶酶体的功能、进入细胞核的功能，并详细介绍了有关基因载体功能化修饰的方法和目前国际上的进展情况，最后本文总结了高聚物载体目前存在的主要问题及未来的发展方向。