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Marc A. Little Jonathan J. Loughrey Amedeo Santoro Malcolm A. Halcrow Michaele J. Hardie 《Tetrahedron letters》2014
The synthesis of four 3,4-di(alkylsulfanyl)benzyl alcohol derivatives is described, in five steps from methyl 3,4-di(hydroxy)benzoate via a Newman–Kwart rearrangement. Incubation of these derivatives in formic acid affords 2,3,7,8,12,13-hexakis(alkylsulfanyl)-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene products, which are hexa-sulfanyl analogues of the well-known supramolecular cavitand host, cyclotriveratrylene (CTV). The yield of this cyclization depends strongly on the alkylsulfanyl substituents present, in the order SMe > SEt ≈ SiPr ? SBn. A crystal structure determination of one of the cyclotrimers shows a mode of self-association that is commonly exhibited by CTV itself. 相似文献
2.
Yoshimasa Makita Tomofumi Danno Keisuke Ikeda Hsien-Han Lee Taro Abe Kento Sogawa Akihiro Nomoto Shin-ichi Fujiwara Akiya Ogawa 《Tetrahedron letters》2017,58(48):4507-4509
Hemicryptophanes are covalent molecular cages, constructed from a cyclotriveratrylene-based host unit and a functional unit linked by covalent spacers, which have been designed to accommodate endohedral functionalities in the cavity. In this study, the synthesis and characterization of the rigid, biphenyl-linked hemicryptophane 1 were investigated by NMR, ESI-MS, and X-ray crystallography. The structure of the inclusion complex, in which a dichloromethane molecule was constructed encapsulated within 1, was characterized by X-ray crystallography. An endohedral, cobalt(II) hemicryptophane complex 2 was also synthesized and characterized ESI-MS and X-ray crystallography. The X-ray crystal structure of 2 showed that the biphenyl-linked hemicryptophane had three components—a molecule each of chloroform and acetonitrile, and a cobalt(II) ion—within its cavity. 相似文献
3.
Carmine Coluccini Yoke Mooi Ng Yves Ira A. Reyes Hsin-Yi Tiffany Chen Yit Lung Khung 《Molecules (Basel, Switzerland)》2020,25(22)
In this paper, a modified Cyclotriveratrylene was synthesized and linked to a branched Polyethylenimine, and this unique polymeric material was subsequently examined as a potential supramolecular carrier for Doxorubicin. Spectroscopic analysis in different solvents had shown that Doxorubicin was coordinated within the hollow-shaped unit of the armed Cyclotriveratrylene, and the nature of the host–guest complex revealed intrinsic Van der Waals interactions and hydrogen bonding between the host and guest. The strongest interaction was detected in water because of the hydrophobic effect shared between the aromatic groups of the Doxorubicin and Cyclotriveratrylene unit. Density functional theory calculations had also confirmed that in the most stable coordination of Doxorubicin with the cross-linked polymer, the aromatic rings of the Doxorubicin were localized toward the Cyclotriveratrylene core, while its aliphatic chains aligned closer with amino groups, thus forming a compact supramolecular assembly that may confer a shielding effect on Doxorubicin. These observations had emphasized the importance of supramolecular considerations when designing a novel drug delivery platform. 相似文献
4.
Abraham Warshawsky Nurit Shoef 《Journal of inclusion phenomena and macrocyclic chemistry》1988,6(6):647-651
Cyclotriveratrylene (CTV) can be readily synthesized by chloromethylation or bromomethylation of dimethoxybenzene with halomethyloctyl ether in the presence of SnCl4. The reaction provides the trimer exclusively and in high yield. Recrystallizations from benzene or CHCl3 yielded the solvent inclusion complexes and did not remove other inclusion impurities. Flash chromatography on silica yielded the pure CTV.13C NMR shows only five signals and no impurities. 相似文献
5.
Four novel cyclotriveratrylene (CTV) derivatives with three benzoate pendants bearing different aliphatic chains have been prepared in good yields, starting from CTV. The complexation behavior of these CTV derivatives towards C60 in arene solvents has been measured by UV‐visible spectroscopy and high complexation constants are obtained. It is observed that the complexation is promoted pronouncedly by introducing methyl ester groups to the aromatic pendants, while this promoting effect is reduced when the methyl groups are replaced by longer alkyl groups. 相似文献
6.
Marlon R. Lutz Jr. 《Tetrahedron letters》2007,48(36):6368-6371
The oxime of cyclotriveratrylene (CTV) has been prepared and the individual crown and saddle conformers were isolated and characterized. The equilibrium constant was measured in CDCl3 and in DMSO-d6 and was shown to favor the crown conformer by an order of magnitude in DMSO-d6, relative to an approximately equal mixture at equilibrium in CDCl3. The time course for interconversion of the saddle to the crown was measured by 1H NMR and the t1/2 of the saddle was determined to be 2.45 h in CDCl3 at 25 °C, and 3.71 h in DMSO-d6. 相似文献
7.
Jennifer A. Wytko Jean Weiss 《Journal of inclusion phenomena and macrocyclic chemistry》1994,19(1-4):207-225
This article describes the attachement of coordination sites around a rigid matrix: cyclotriveratrylene (CTV). The synthetic approaches leading to these new ligands possessing pyridines and bipyridines as coordinating sites are discussed and full synthetic details are given. One expanded CTV derivative bearing three 3-pyridyl groups has been characterized by X-ray crystallography and the structure shows that the conformation adopted by the CTV matrix is appropriate for the coordination of transition metals, and inclusion of a range of molecules in the hydrophobic pocket.This paper is dedicated to the commemorative issue on the 50th anniversary of calixarenes. 相似文献
8.
Ruksanna Ahmad 《Supramolecular chemistry》2013,25(1):29-38
Cyclotriveratrylene (CTV) derived host molecules with ethyl, propyl, allyl or propargyl functional groups have been synthesised using standard or solventless reaction methodologies. The known structural and clathrate chemistry of cyclotriveratrylene (CTV) and these analogues has been extended. Crystal structures of the hexa(ethyl), tri(ethyl), tri(propargyl) analogues have been determined, and show either intra-cavity host-guest binding or self-stacking motifs. Two new clathrates of CTV have also been structurally characterised, namely CTV.(DMSO)2.(H2O)2 with intra-cavity complexation of DMSO, and CTV.(EtOH)0.25 which has a γ-phase CTV structure. 相似文献
9.
Inclusion compounds were formed between the host cyclotriveratrylene, H, (2,3,7,8,12,13-hexamethoxy-5,10-dihydro-15H-tribenzo[a,d,g]cyclononene) and the guests carbon tetrachloride, 1,1,1-trichloroethane, 1,1,1-trichloropropane and 1,1,2-trichloroethane. 1 (H·CCl4) has guest molecules in channels alternating with channels of host molecules. 2 (H·C2H3Cl3·C3H5Cl3) and 3 (H·2C2H3Cl3) exhibit a slightly different packing arrangement with one guest molecule in the host cavity and the rest of the guest molecules in channels. The stability and reactivity of these inclusion compounds were investigated. 相似文献
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