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Magnus Rueping Prof. Dr. Alexander Kuenkel Dipl.‐Chem. Francisco Tato Dr. Jan W. Bats Dr. 《Angewandte Chemie (International ed. in English)》2009,48(20):3699-3702
C′mon 1,2‐dione : A new diastereo‐ and enantioselective Lewis base catalyzed domino Michael/aldol reaction converts α,β‐unsaturated aldehydes and 1,2‐diones into chiral bicyclo[3.2.1]octane‐6‐carbaldehydes. The products are produced in good to excellent enantioselectivities (90–98 % ee) and can be transformed into bicyclic diols and triols. Additionally, a retro‐aldol cyclization provides access to valuable tetrahydrochromenones (see scheme).
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Manojit Pal Venkataraman SubramanianKaruppasamy Parasuraman Koteswar Rao Yeleswarapu 《Tetrahedron》2003,59(48):9563-9570
(S)-Prolinol facilitated the coupling reaction of terminal alkynes with 3-iodoflavone under palladium-copper catalysis in aqueous DMF affording a mild and convenient method for the synthesis of 3-alkynyl substituted flavones of potential biological interest. 相似文献
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Aromatic aldehydes were reduced to the corresponding hydrocarbons with borohydride exchange resin (BER) - nickel acetate in methanol in excellent yields. 相似文献
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首次合成了α,α-L-二芳基脯氨醇-吡啶衍生物:S-二(4-(吡啶-4-基)苯基)(吡咯烷-2-基)甲醇(L),并用其与硝酸银自组装出具有梯形链结构的一维手性Ag(Ⅰ)配位聚合物{[Ag4(L)4](NO3)4·1.5CH3OH·1.25H2O}n(1);用IR、XRD、TG、粉末XRD和单晶XRD对聚合物结构进行了表征。圆二色谱和二次谐波响应测试也证明了它具有结构上的手性。此外,还研究了其荧光性质。 相似文献
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E. D. Matveeva T. A. Podrugina I. G. Morozkin S. E. Tkachenko N. S. Zefirov 《Chemistry of Heterocyclic Compounds》2000,36(10):1149-1153
A method has been developed for the synthesis of isosteric analogs of nicotine involving ethers of S(-)-1-2-pyrrolidinemethanol and S(-)-1-2-pyrrolidineethanol based on the Mitsunobu reaction. The results of testing the synthesized compounds as calcium channel blockers are presented. 相似文献
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Johnathan E. Holladay Todd A. Werpy Danielle S. Muzatko 《Applied biochemistry and biotechnology》2004,115(1-3):857-869
Technology to convert biomass into chemical building blocks provides an opportunity to displace fossil fuels and increase
the economic viability of biorefineries. Coupling fermentation capability with aqueous-phase catalysis provides novel routes
to monomers and chemicals, including those not accessible from petrochemical routes. Glutamic acid provides a platform to
numerous compounds through thermochemical approaches including hydrogenation, cyclization, decarboxylation, and deamination.
Hydrogenation of amino acids also provides access to chiral compounds with high enantiopurity. This article detals aqueous-phase
hydrogenation reactions that we have developed that lead to valuable chemical intermediates from glutamic acid. In addition,
13C nuclear magnetic resonance and matrix-assisted laser desorption ionization mass spectral data are presented that provide
a mechanistic picture of the reactions. The results show that hydrogenation of glutamic acid has unique characteristics from
other amino acids and that paradigms in the literature do not hold up for this transformation. 相似文献
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A novel Fe(II)/diaryl prolinol catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with alkenes has been developed. In the presence of FeCl2 (10 mol %) and α,α-bis(3,5-bistrifluoromethylphenyl)prolinol L1 (10 mol %), [3+2] cycloaddition of azomethine ylides with electronic-deficient olefins underwent smoothly in CH3CN at room temperature to generate the desired endo-adducts in moderate to good yields and enantioselectivities. This is the first example of Fe(II)/N,O-ligand (L1) catalyzed 1,3-dipolar enantioselective cycloaddition reaction of azomethine ylides. 相似文献
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