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Xiuxiu Wang Yi Hu Jianbin Mo Jingyi Zhang Zhenzhen Wang Wei Wei Huanlin Li Yun Xu Jing Ma Jing Zhao Zhong Jin Zijian Guo 《Angewandte Chemie (International ed. in English)》2020,59(13):5151-5158
Arsenene has recently emerged as a promising new two‐dimensional material for biomedical applications because of its excellent optical and electronic properties. Herein, novel 2D arsenene nanosheets were synthesized and shown to be effective against NB4 promyelocytic leukaemia (APL) cells (82 % inhibition) as well as inducing apoptosis while showing no toxicity towards normal cells. The high zeta potential, small size, and the planar structure were crucial to the toxicity of the materials. Label‐free proteomic profiling analysis suggested that arsenene affected nuclear DNA replication, nucleotide excision repair, and pyrimidine metabolism pathways by downregulating the DNA polymerases POLE, POLD1, POLD2, and POLD3. Mass spectrometric studies showed that arsenene bound mainly to nuclear nucleotide acid binding proteins in NB4 cells and further cellular fluorescence studies revealed that the arsenene destroyed the nuclei. In vivo toxicity tests in mice also indicated the physiological biosafety of arsenene. 相似文献
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Spin-dependent transport characteristics of nanostructures based on armchair arsenene nanoribbons 下载免费PDF全文
By employing non-equilibrium Green's function combined with the spin-polarized density-functional theory, we investigate the spin-dependent electronic transport properties of armchair arsenene nanoribbons(a As NRs). Our results show that the spin-metal and spin-semiconductor properties can be observed in a As NRs with different widths. We also find that there is nearly 100% bipolar spin-filtering behavior in the a As NR-based device with antiparallel spin configuration. Moreover, rectifying behavior and giant magnetoresistance are found in the device. The corresponding physical analyses have been given. 相似文献
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Jiri Sturala Zdenek Sofer Martin Pumera 《Angewandte Chemie (International ed. in English)》2019,58(23):7551-7557
Materials with few layers have been subjected to extensive research for the last few decades owing to their remarkable properties as for example catalysts, optical and electrical devices, or sensors. The properties and electronic structure of these materials can be tailored by the introduction of substituents. In the case of more reactive species, the modification also can improve stability, which is also an important factor with respect to device fabrication. This review focuses on monoelemental layered materials of Group 15 elements (pnictogens) and in particular their modification, leading to better ambient stability and/or different properties by covalent and non‐covalent modifications. The future modification and application of pnictogens are outlined. 相似文献
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Dr. Andrey A. Kistanov Prof. Dr. Salavat Kh. Khadiullin Prof. Dr. Sergey V. Dmitriev Elena A. Korznikova 《Chemphyschem》2019,20(4):575-580
Arsenene, a new group-V two-dimensional (2D) semiconducting material beyond phosphorene and antimonene, has recently gained an increasing attention owning to its various interesting properties which can be altered or intentionally functionalized by chemical reactions with various molecules. This work provides a systematic study on the interactions of arsenene with the small molecules, including H2, NH3, O2, H2O, NO, and NO2. It is predicted that O2, H2O, NO, and NO2 are strong acceptors, while NH3 serves as a donor. Importantly, it is shown a negligible charge transfer between H2 and arsenene which is ten times lower than that between H2 and phosphorene and about thousand times lower than that between H2 and InSe and antimonene. The calculated energy barrier for O2 splitting on arsenene is found to be as low as 0.67 eV. Thus, pristine arsenene may easily oxidize in ambient conditions as other group V 2D materials. On the other hand, the acceptor role of H2O on arsenene, similarly to the cases of antimonene and InSe, may help to prevent the proton transfer between H2O and O− species by forming acids, which suppresses further structural degradation of arsenene. The structural decomposition of the 2D layers upon interaction with the environment may be avoided due to the acceptor role of H2O molecules as the study predicts from the comparison of common group V 2D materials. However, the protection for arsenene is still required due to its strong interaction with other small environmental molecules. The present work renders the possible ways to protect arsenene from structure degradation and to modulate its electronic properties, which is useful for the material synthesis, storage and applications. 相似文献
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Xinyang Zhao Xingyun Wang Wei Zhang Tian Tian Jingyi Zhang Jing Wang Prof. Wei Wei Prof. Zijian Guo Prof. Jing Zhao Xiuxiu Wang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2024,136(15):e202400829
Due to multidrug resistance and the high risk of recurrence, effective and less toxic alternative pancreatic cancer treatments are urgently needed. Pancreatic cancer cells are highly resistant to apoptosis but sensitive to ferroptosis. In this study, an innovative nanoplatform ( AsIr@PDA ) was developed by electrostatic adsorption of a cationic iridium complex ( IrFN ) onto two-dimensional (2D) arsenene nanosheets. This nanoplatform exhibits superior ferroptosis-inducing effects with high drug loading capacity and, importantly, excellent anti-cancer immune activation function, leading to efficient elimination of pancreatic tumors with no observable side effects. Interestingly, AsIr@PDA significantly prevents the recurrence of pancreatic cancer in vivo when compared with a cisplatin-loaded nanoplatform. This designed nanoplatform demonstrated superior therapeutic efficacy by synergistic ferroptosis-induced chemotherapy with immunotherapy via an all-in-one strategy, providing new insights for future pancreatic cancer therapy. 相似文献
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石墨烯的零带隙和二硫化钼载流子迁移率低的性质阻碍了它们在电子器件中的应用。单层黑磷的成功制备和磷烯的直接带隙、较高的载流子迁移率和负的泊松比等性质弥补了石墨烯和二硫化钼的不足,引发了人们对低维第五主族纳米材料的研究兴趣,使低维第五主族纳米材料在材料科学和光电子等领域快速发展。本文总结了近几年第五主族低维纳米材料的一些研究成果,结合理论计算和实验合成两个方面进行研究,分析了材料的结构和性能之间的关系,最后对上述材料的制备方法及应用情况进行了总结。低维第五主族纳米材料呈现出多种晶体结构、较高的动力学稳定性、丰富的电子结构性质和较高的载流子迁移率等特性。上述性质使得低维第五主族纳米材料在低维光电子器件等方面具有广泛的应用前景。 相似文献
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