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Reyhan BastinJames W. Dale Michael G. EdwardsJulien P.N. Papillon Michael R. WebbRichard J.K. Taylor 《Tetrahedron》2011,67(51):10026-10044
A formal synthesis of neooxazolomycin is described via the preparation of Kende’s key intermediate in a longest linear sequence of 23 steps. This work is founded upon the union of three fragments: Moloney’s lactam-derived triflate, a vinyl stannane and a Julia-Kocienski sulfone and encompasses three key steps: (i) a Stille cross-coupling to combine the triflate and vinyl stannane, (ii) a base-promoted enone deconjugation to derive the dihydroxylation precursor and (iii) our previously reported Julia-Kocienski methodology to assemble the pentadienyl amine side chain with the sulfone precursor. 相似文献
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