On the Determination of the Number of Components from Simulated Spectra Using Kalmanfiltering

Abstract

A KalmanfiIter is designed to determine the number of components in multicomponentmixtures. Spectra of different mixtures are simulated and processed sequentially in the Kalmanfilter. It is shown that the number of components present in the sample as well as their concentrations can be determined simultaneously. Moreover, the proposed method is attractive from a computational point of view.     

The Simultaneous Spectrophotometric Assay of the Active Constituents of Multicomponent Analgesics Using Kalmanfiltering

Abstract

UV-spectrophotometry in combination with Kalmanfiltering is used for the assay of analgesics in tablets. Commercial products containing various combinations of acetylsalicylic acid, salicylic acid, caffeine, phenacetine and acetaminophen are analyzed. For comparison, these tablets were also analyzed by HPLC. The accuracy and precision of both methods are comparable. The described spectrophotometric assay with the aid of Kalmanfiltering represents a new, rapid and low-cost alternative to existing analytical procedures for analgesics.