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Le' an Hu Yao Zhang Qing-Wen Zhang Qin Yin Xumu Zhang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(13):5359-5363
A Ru-catalyzed direct asymmetric reductive amination of ortho-OH-substituted diaryl and sterically hindered ketones with ammonium salts is reported. This method represents a straightforward route toward the synthesis of synthetically useful chiral primary diarylmethylamines and sterically hindered benzylamines (up to 97 % yield, 93–>99 % ee). Elaborations of the chiral amine products into bioactive compounds and a chiral ligand were demonstrated through manipulation of the removable and convertible -OH group. 相似文献
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A Pd-catalyzed coupling-type reaction of aldehydes and organoboronic acids was achieved in the presence of P(1-nap)3, using Cs2CO3 in toluene, providing diaryl ketones with yields ranged from moderate to excellent. The efficiency of this reaction was demonstrated by the compatibility with nitro, cyano, trifluoromethyl, fluoro and chloro groups. Moreover, the rigorous exclusion of air/moisture is not required in these transformations. 相似文献
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Weiwei Zhang 《Tetrahedron letters》2008,49(36):5336-5338
A CsOH-promoted aerobic oxidation of sec-aromatic alcohols has been developed, using air as a free and clean oxidant, and providing aryl ketones in good to excellent yields. 相似文献
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Asymmetric epoxidation of methyl gibberellate by the modified Sharpless reagent in the various temperature is described. Compound 8 and 9 can be used as the key intermediates for synthesis of the polyhydroxygibberellins. 相似文献
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