Events and Observables in Generally Invariant Spacetime Theories

We address the problem of observables in generally invariant spacetime theories such as Einstein’s general relativity. Using the refined notion of an event as a “point-coincidence” between scalar fields that completely characterise a spacetime model, we propose a generalisation of the relational local observables that does not require the existence of four everywhere invertible scalar fields. The collection of all point-coincidences forms in generic situations a four-dimensional manifold, that is naturally identified with the physical spacetime.     

LC-MS/MS Analysis and Comparison of Oxidative Damages on Peptides Induced by Pathogen Reduction Technologies for Platelets

Pathogen reduction technologies (PRT) are photochemical processes that use a combination of photosensitizers and UV-light to inactivate pathogens in platelet concentrates (PCs), a blood-derived product used to prevent hemorrhage. However, different studies have questioned the impact of PRT on platelet function and transfusion efficacy, and several proteomic analyses revealed possible oxidative damages to proteins. The present work focused on the oxidative damages produced by the two main PRT on peptides. Model peptides containing residues prone to oxidation (tyrosine, histidine, tryptophane, and cysteine) were irradiated with a combination of amotosalen/UVA (Intercept process) or riboflavin/UVB (Mirasol-like process). Modifications were identified and quantified by liquid chromatography coupled to tandem mass spectrometry. Cysteine-containing peptides formed disulfide bridges (R-SS-R, ?2 Da; favored following amotosalen/UVA), sulfenic and sulfonic acids (R-SOH, +16 Da, R-SO₃H, +48 Da, favored following riboflavin/UVB) upon treatment and the other amino acids exhibited different oxidations revealed by mass shifts from +4 to +34 Da involving different mechanisms; no photoadducts were detected. These amino acids were not equally affected by the PRT and the combination riboflavin/UVB generated more oxidation than amotosalen/UVA. This work identifies the different types and sites of peptide oxidations under the photochemical treatments and demonstrates that the two PRT may behave differently. The potential impact on proteins and platelet functions may thus be PRT-dependent.

Optical Space of the Reissner-Nordström Solutions

We present an exhaustive discussion of the embedding diagrams for the optical geometry of the Reissner-Nordström solutions. Whereas in the black hole sector there are no qualitative differences with respect to the Schwarzschild case, the diagrams are considerably different if naked singularities are present. Our treatment is sufficiently general that it can be applied also to any other static spherically symmetric spacetime.     

Faster-than-c Signals, Special Relativity, and Causality

Motivated by the recent attention on superluminal phenomena, we investigate the compatibility between faster-than-c propagation and the fundamental principles of relativity and causality. We first argue that special relativity can easily accommodate—indeed, does not exclude—faster-than-c signaling at the kinematical level. As far as causality is concerned, it is impossible to make statements of general validity, without specifying at least some features of the tachyonic propagation. We thus focus on the Scharnhorst effect (faster-than-c photon propagation in the Casimir vacuum), which is perhaps the most plausible candidate for a physically sound realization of these phenomena. We demonstrate that in this case the faster-than-c aspects are “benign” and constrained in such a manner as to not automatically lead to causality violations.     

Hawking-like radiation does not require a trapped region

We discuss the issue of quasiparticle production by "analogue black holes" with particular attention paid to the possibility of reproducing Hawking radiation in a laboratory. By constructing simple geometric acoustic models, we obtain a somewhat unexpected result: We show that, in order to obtain a stationary and Planckian emission of quasiparticles, it is not necessary to create a trapped region in the acoustic spacetime (corresponding to a supersonic regime in the fluid flow). It is sufficient to set up a dynamically changing flow asymptotically approaching a sonic regime with sufficient rapidity in laboratory time. This result is generic to curved-space quantum field theory, the "analogue spacetimes" we consider providing a guide to physical intuition, and a possible route to laboratory experiments.     

Synthesis of 6,19-cyclopregnanes. Constrained analogues of steroid hormones

A procedure for the synthesis of 6,19-cyclopregnanes is described involving an intramolecular alkylation reaction of Delta(4)-3-keto steroids with a 19-mesylate in the presence of KOH in isopropanol. Three 6,19-cyclopregnanes were prepared (4, 5 ,9); in the rat, 6,19-cycloprogesterone (4) and its 21-hydroxy derivative 5 displaced [3H]-dexamethasone from glucocorticoid receptors, the former compound being more active. Both compounds did not compete with [3H]-aldosterone for kidney mineralocorticoid receptors nor with [3H]-R5020 for uterus progesterone receptors.     

On the tail problem in cosmology

The tail problem for the propagation of a scalar field is considered in a cosmological background, taking a Robertson-Walker spacetime as a specific example. The explicit radial dependence of the general solution of the Klein-Gordon equation with non-minimal coupling is derived, and the inapplicability of the standard calculation of the reflection and transmission coefficients to the study of scattering of waves by the cosmological curvature is discussed.     

Linking the trans-Planckian and information loss problems in black hole physics

The trans-Planckian and information loss problems are usually discussed in the literature as separate issues concerning the nature of Hawking radiation. Here we instead argue that they are intimately linked, and can be understood as “two sides of the same coin” once it is accepted that general relativity is an effective field theory.     

Interpretation of the hydrodynamical formalism of quantum mechanics

The hydrodynamical formalism for the quantum theory of a nonrelativistic particle is considered, together with a reformulation of it which makes use of the methods of kinetic theory and is based on the existence of the Wigner phase-space distribution. It is argued that this reformulation provides strong evidence in favor of the statistical interpretation of quantum mechanics, and it is suggested that this latter could be better understood as an almost classical statistical theory. Moreover, it is shown how, within this context, the Wigner and the Margenau-Hill functions are not equivalent, and that the latter is essentially unsatisfactory, as well as the associated symmetrization rule. Arguments in favor of a stochastic picture of the phenomena at the microscopic level are also presented.