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1.
Journal of Global Optimization - 相似文献
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Leandro Marcondes-Alves Victor Fattori Sergio M. Borghi Yuri Lourenco-Gonzalez Allan J.C. Bussmann Elisa Y. Hirooka 《Natural product research》2019,33(6):921-924
Acetaminophen (paracetamol) is a widely used analgesic and antipyretic drug that is safe at therapeutic doses. However, acetaminophen overdose can be fatal. Currently, the only treatment available is the N-acetyl cysteine. The diterpene kaurenoic acid (ent-kaur-16-en-19-oic acid, KA) is the major constituent of Sphagneticola trilobata (L.) Pruski. KA presents anti-inflammatory, anti-nociceptive and antioxidant properties. In this study, we evaluated the efficacy of KA in a model of acetaminophen-induced hepatotoxicity. KA increased, in a dose-dependent manner, the survival rate after acetaminophen overdose. KA reduced acetaminophen-induced hepatic necrosis and ALT and AST levels. KA decreased acetaminophen-induced neutrophil and macrophage recruitment, oxidative stress and the production of IL-33, TNF-α and IL-1β, alongside with normalisation of IL-10 levels in the liver. Therefore, KA showed preclinical efficacy in acetaminophen-induced hepatotoxicity and lethality. 相似文献
3.
Schmalian Misha Suris Yuri B. Tumarkin Yuriy 《Mathematical Physics, Analysis and Geometry》2021,24(4):1-17
Mathematical Physics, Analysis and Geometry - In this paper, we develop the dressing method to study the modified Camassa-Holm equation with the help of reciprocal transformation and the associated... 相似文献
4.
Osipov Dmitriy V. Artyomenko Alina A. Osyanin Vitaly A. Klimochkin Yuri N. 《Chemistry of Heterocyclic Compounds》2019,55(3):261-265
Chemistry of Heterocyclic Compounds - Reactions of 4Н-chromene-3-carbaldehydes and 1Н-benzo[f]chromene-3-carbaldehydes with 4-aminocoumarin were used to obtain a series of... 相似文献
5.
Tatiana A. Vovk Semyon S. Rudyi Andrei V. Ivanov Evgeniy Y. Perlin Yuri V. Rozhdestvensky 《Physics letters. A》2019,383(9):923-928
One of the most interesting problems of modern physics is the realization of nanoparticles in macroscopic quantum states, in which they behave as a quantum objects. These states can only be implemented at ultra-low translational temperatures that have not been achieved so far. Here we develop a novel method for optical cooling of CaF2:Yb3+ nanocrystals, which is based on the coherent population transfer induced in the impurity ions by ultraviolet Raman pulses. A doped nanocrystal localized in a radio-frequency trap is cooled due to the photon recoil from the pulses of varied intensity. The proposed method allows to obtain nanocrystals with translational temperatures of the order of 10?9 K, which indicates that the nanocrystal approaches a macroscopic quantum state. 相似文献
6.
Sadagov A. Yu. Goidina T. A. Aseev V. A. Nikonorov N. V. Fedorov Yu. K. Chugunova M. M. Levin A. D. 《Optics and Spectroscopy》2020,128(10):1658-1666
Optics and Spectroscopy - The results of development of fluorescence calibration standards based on phosphate matrix glass activated with ions of rare-earth metals are presented. The calibration... 相似文献
7.
Cover Picture: Coordination Chemistry of N‐Heterocyclic Nitrenium‐Based Ligands (Chem. Eur. J. 19/2015) 下载免费PDF全文
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A non‐iterative implicit algorithm for the solution of advection–diffusion equation on a sphere 下载免费PDF全文
Yuri N. Skiba 《国际流体数值方法杂志》2015,78(5):257-282
A numerical algorithm for the solution of advection–diffusion equation on the surface of a sphere is suggested. The velocity field on a sphere is assumed to be known and non‐divergent. The discretization of advection–diffusion equation in space is carried out with the help of the finite volume method, and the Gauss theorem is applied to each grid cell. For the discretization in time, the symmetrized double‐cycle componentwise splitting method and the Crank–Nicolson scheme are used. The numerical scheme is of second order approximation in space and time, correctly describes the balance of mass of substance in the forced and dissipative discrete system and is unconditionally stable. In the absence of external forcing and dissipation, the total mass and L2‐norm of solution of discrete system is conserved in time. The one‐dimensional periodic problems arising at splitting in the longitudinal direction are solved with Sherman–Morrison's formula and Thomas's algorithm. The one‐dimensional problems arising at splitting in the latitudinal direction are solved by the bordering method that requires a prior determination of the solution at the poles. The resulting linear systems have tridiagonal matrices and are solved by Thomas's algorithm. The suggested method is direct (without iterations) and rapid in realization. It can also be applied to linear and nonlinear diffusion problems, some elliptic problems and adjoint advection–diffusion problems on a sphere. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献