Modeling the motion of a bright spot in jets from black holes M87* and SgrA*

General Relativity and Gravitation - In previous work, we established theoretical results concerning the effect of matter shells surrounding a gravitational wave (GW) source, and we now apply these...     

The Cytotoxic Effect of α-Synuclein Aggregates

Parkinson's disease is a neurodegenerative disorder involving a functional protein, α-synuclein, whose primary function is related to vesicle trafficking. However, α-synuclein is prone to form aggregates, and these inclusions, known as Lewy bodies, are the hallmark of Parkinson's disease. α-synuclein can alter its conformation and acquire aggregating capacity, forming aggregates containing β-sheets. This protein's pathogenic importance is based on its ability to form oligomers that impair synaptic transmission and neuronal function by increasing membrane permeability and altering homeostasis, generating a deleterious effect over cells. First, we establish that oligomers interfere with the mechanical properties of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) membrane, as demonstrated by nanoindentation curves. In contrast, nanoindentation revealed that the α-synuclein monomer's presence leads to a much more resistant lipid bilayer. Moreover, the oligomers’ interaction with cell membranes can promote lactate dehydrogenase (LDH) release, suggesting the activation of cytotoxic events.     

Condensation of all-cis-tetraphenylcyclotetrasiloxanetetraol in ammonia: new method for preparation of ladder-like polyphenylsilsesquioxanes

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Thermally induced solid-state transformation of cimetidine. A multi-spectroscopic/chemometrics determination of the kinetics of the process and structural elucidation of one of the products as a stable N3-enamino tautomer

Exposure of cimetidine (CIM) to dry heat (160–180 °C) afforded, upon cooling, a glassy solid containing new and hitherto unknown products. The kinetics of this process was studied by a second order chemometrics-assisted multi-spectroscopic approach. Proton and carbon-13 nuclear magnetic resonance (NMR), as well as ultraviolet and infrared spectroscopic data were jointly used, whereas multivariate curve resolution with alternating least squares (MCR-ALS) was employed as the chemometrics method to extract process information. It was established that drug degradation follows a first order kinetics.     

Multicriteria decision making under uncertainty

Formalization for problems of multicriteria decision making under uncertainty is constructed in terms of guaranteed and weak estimates. A relevant definition of the vector maximinimax value is given. Parameterization and approximation of maximum, minimax, and maximinimax values based on the inverse logical convolution are suggested. An application for multicommodity networks is considered. Received: December 13, 2000 / Accepted: August 21, 2001?Published online May 8, 2002     

Thermoelastic-plastic stress state of shells of revolution reinforced by annular ribs

Institute of Mechanics, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Prikladnaya Mekhanika, Vol. 27, No. 1, pp. 50–55, January, 1991.     

Elastoplastic state of axisymmetrically loaded laminated bodies of revolution made of isotropic and orthotropic materials

Institute of Mechanics, Ukrainian Academy of Sciences, Kiev. Translated from Prikladnaya Mekhanika, Vol. 28, No. 1, pp. 31–39, January, 1992.     

Use of Surfactant-Stabilized Emulsions for the Alkalimetric Determination of Indometacin

The proton-donor properties of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid (indometacin) were studied in emulsions based on different surfactants and their mixtures. A procedure for the alkalimetric titration of indometacin with detecting the titration end-point in the presence of Cresol Red was developed using an emulsion based on dodecylpyridinium chloride. The conditions for determining indometacin in medicinal forms by pH-metric titration were selected.     

Study of the viscoelastoplastic deformation of an element of a body with a three-branch loading path

Institute of Mechanics, Academy of Sciences of the Ukraine, Kiev. Translated from Prikladnaya Mekhanika, Vol. 27, No. 12, pp. 26–33, December, 1991.