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1.
Circulating tumor cells (CTCs) have been proven to have significant prognostic, diagnostic, and clinical values in early-stage cancer detection and treatment. The efficient separation of CTCs from peripheral blood can ensure intact and viable CTCs and can, thus, give proper genetic characterization and drug innovation. In this study, continuous and high-throughput separation of MDA-231 CTCs from overlapping sized white blood cells (WBCs) is achieved by modifying inertial cell focusing with dielectrophoresis (DEP) in a single-stage microfluidic platform by numeric simulation. The DEP is enabled by embedding interdigitated electrodes with alternating field control on a serpentine microchannel to avoid creating two-stage separation. Rather than using the electrokinetic migration of cells which slows down the throughput, the system leverages the inertial microfluidic flow to achieve high-speed continuous separation. The cell migration and cell positioning characteristics are quantified through coupled physics analyses to evaluate the effects of the applied voltages and Reynolds numbers (Re) on the separation performance. The results indicate that the introduction of DEP successfully migrates WBCs away from CTCs and that separation of MDA-231 CTCs from similar sized WBCs at a high Re of 100 can be achieved with a low voltage of magnitude 4 ×106 V/m. Additionally, the viability of MDA-231 CTCs is expected to be sustained after separation due to the short-term DEP exposure. The developed technique could be exploited to design active microchips for high-throughput separation of mixed cell beads despite their significant size overlap, using DEP-modified inertial focusing controlled simply by adjusting the applied external field.  相似文献   
2.
Molecular Diversity - We herein report the facile synthesis of a series of 3,5-substituted-1,2,4-oxadiazole derivatives in good to excellent yields. The anti-inflammatory potential of the newly...  相似文献   
3.
Journal of Russian Laser Research - Laser side-pumping approach is an extremely attractive configuration for many laser applications. Through this approach, the laser beam can be generated in the...  相似文献   
4.
Russian Journal of General Chemistry - A highly efficient synthetic methodology for the preparation of 2-thioxocytosine was achieved by the nucleophilic addition of thiourea to...  相似文献   
5.
Journal of Cluster Science - Many environmental hazards are due to chemical insecticides and enhance mosquito species' resistance. This problem is solved by using safer nanocides that reduce...  相似文献   
6.
7.
Journal of Thermal Analysis and Calorimetry - In the present paper, the performance of the graphene oxide in the solar steam generation has experimentally been examined. For this purpose, a setup...  相似文献   
8.
Journal of Thermal Analysis and Calorimetry - Willemite is an inorganic semiconductor material used for optoelectronic applications. The present study purposes a new polymer thermal treatment...  相似文献   
9.
Journal of Thermal Analysis and Calorimetry - Flow boiling heat transfer widely utilized in numerous industrial applications such as boiler tubes, evaporators and cooling of reactors in a nuclear...  相似文献   
10.
The carrot plant (Daucus carota) and its components are traditionally reported for the management of gastric ulcers. This study was performed to evaluate the role of carrot when administered concurrently with a conventional antiulcer treatment, pantoprazole, in alleviating gastric and duodenal ulcers in female experimental animals. The study involved standard animal models to determine the ulcer preventive effect using pylorus ligation, ethanol, and stress induced acute gastric ulcer models and duodenal ulcer models involving cysteamine. Acetic acid-induced chronic gastric ulcer and indomethacin-induced gastric ulcer models were used to evaluate the ulcer healing effect. Carrot fruit (500 mg/kg) and its co-administration with pantoprazole produced significant protection in an ethanol- and stress-induced acute gastric ulcer and cysteamine-induced duodenal ulcer. The healing of the acetic acid-induced chronic gastric ulcer was also augmented with this combination. Both total proteins and mucin contents were significantly increased in indomethacin-induced gastric ulcers. Similarly, in pylorus ligation, the pepsin content of gastric juice, total acidity, and free acidity were reduced. Overall, both ulcer preventive effects and ulcer healing properties of the pantoprazole were significantly enhanced in animals who received the co-administration of carrot fruit (500 mg/kg).  相似文献   
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