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1.
Ginkgolide B is a dietary diterpene with multiple pharmacological activities. However, current research on ginkgolide B is not comprehensive. The current study analyzed the metabolic profile of ginkgolide B in vivo and in vitro using ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry. To detect and identify the different metabolites in ginkgolide B, a novel data processing method was used as an assistant tool. A total of 53 different metabolites of ginkgolide B (38 phase I metabolites and 15 phase II metabolites) were detected relative to blank samples. The biotransformation route of ginkgolide B was identified as oxidation, dehydroxylation, hydrogenation, decarbonylation, demethylation, sulfate conjugation, glucose conjugation, methylation, and acetylation. The current study demonstrated a method for rapidly detecting and identifying metabolites and provided useful information to further characterize the pharmacology and mechanism of ginkgolide B. A method for the analysis of other diterpene metabolic components in vivo and in vitro was also established.  相似文献   
2.
The European Physical Journal B - Molecular dynamics and Monte Carlo methods are common measurements to study the diffusion coefficients of the fluid particles under restricted conditions. Here,...  相似文献   
3.
Yin  Qingqing  Xu  Fen  Sun  Lixian  Li  Yaying  Liao  Lumin  Wang  Tao  Guan  Yanxun  Xia  Yongpeng  Zhang  Chenchen  Wei  Sheng  Zhang  Huanzhi  Li  Bin 《Journal of Thermal Analysis and Calorimetry》2022,147(12):6583-6592
Journal of Thermal Analysis and Calorimetry - Polyethylene glycol (PEG) is widely used as phase change materials (PCMs). However, the leakage and low thermal conductivity issues restrict its...  相似文献   
4.
嵌段共聚物 (BCP) 薄膜可通过不同的退火方法诱导其微相分离,从而获得大面积圆柱状、层状和球状等纳米图案。这些长程有序的纳米结构形态,已经广泛应用在纳米光刻和电子器件等多个领域中。目前,有效且快速的退火方法仍然是BCP薄膜自组装技术中的研究热点。本文首先介绍了制备BCP薄膜纳米结构图案常用的退火技术,然后综述了三种新型快速退火技术,最后分析总结了这些退火技术的优缺点。  相似文献   
5.
In this paper, we derive the Lindblad and Redfield forms of the master equation based on the Born–Markov master equation with and without the secular approximation for open multi-level quantum systems. The coefficients of the equations are re-evaluated according to the scheme in[(2019), Phys. Rev. A 99, 022118]. They are complex numbers rather than the real numbers obtained from traditional simplified methods. The dynamics of two models(one is an open threelevel quantum system model, and the other is the model of phycoerythrin 545(PE545) in a photosynthesis system) are studied. It is shown that the secular approximation and the simplified real coefficients may cause a small distortion of the dynamics in some environments, but a large distortion of the dynamics in others. These effects are discussed and characterized by studying the dynamics of nontrivial instances of multi-level systems in the presence of dissipation.  相似文献   
6.
We simulate the polarization manipulation of bright-dark vector bisolitons at 1-μm wavelength regime.Through changing the pulse parameters,different kinds of pulse shapes and optical spectra are generated in output orthogonal polarization directions.When the input vector bisoliton is polarization-locked with 1064 nm central wavelength,“1+1”fundamental dark-dark and“2+1”pseudo-high-order bright-dark group-velocity-locked vector solitons can be achieved through changing the projection angle.When the input vector bisoliton is group-velocity-locked with 1063 nm and 1065 nm central wavelengths,“2+1”and“2+2”pseudo-high-order bright-dark group-velocity-locked vector solitons,bright-dark group-velocity-locked vector solitons with chirp-like temporal oscillations are generated.Our simulation results can provide beneficial conduct for polarization manipulation of vector multi-solitons,and have promising applications in quantum information register,optical communications,nanophotonics,and all-optical switching.  相似文献   
7.
Ulcerative colitis, an inflammatory bowel disease, is a chronic inflammatory disorder that results in ulcers of the colon and rectum without known etiology.Ulcerative colitis causes a huge public health care burden particularly in developed countries.Many studies suggest that ulcerative colitis results from an abnormal immune response against components of commensal microbiota in genetically susceptible individuals.However, understanding of the disease mechanisms at cellular and molecular levels remains largely elusive.In this paper, a network model is developed based on our previous study and computer simulations are performed using an agent-based network modeling to elucidate the dynamics of immune response in ulcerative colitis progression.Our modeling study identifies several important positive feedback loops as a driving force for ulcerative colitis initiation and progression.The results demonstrate that although immune response in ulcerative colitis patients is dominated by anti-inflammatory/regulatory cells such as alternatively activated macrophages and type Ⅱ natural killer T cells, proinflammatory cells including classically activated macrophages, T helper 1 and T helper 17 cells, and their secreted cytokines tumor necrosis factor-α, interleukin-12, interleukin-23, interleukin-17 and interferon-γ remain at certain levels (lower than those in Crohn's disease, another inflammatory bowel disease).Long-term exposure to these proinflammatory components, causes mucosal tissue damage persistently, leading to ulcerative colitis.Our simulation results are qualitatively in agreement with clinical and laboratory measurements, offering novel insight into the disease mechanisms.  相似文献   
8.
9.
Tanshinol borneol ester (DBZ) is a potential drug candidate composed of danshensu and borneol. It shows anti‐ischemic and anti‐atherosclerosis activity. However, little is known about its metabolism in vivo. This research aimed to elucidate the metabolic profile of DBZ through analyzing its metabolites using high‐performance liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight mass spectrometry. Chromatographic separation was performed on an Agilent TC‐C18 column (150 × 4.6 mm, 5.0 μm) with gradient elution using methanol and water containing 0.2% (v/v) formic acid as the mobile phase. Metabolite identification involved analyzing the retention behaviors, changes in molecular weights and MS/MS fragment patterns of DBZ and its metabolites. As a result, 20 potential metabolites were detected and tentatively identified in rat plasma, urine and feces after administration of DBZ. DBZ could be metabolized to O‐methylated DBZ, DBZ‐O‐glucuronide, O‐methylated DBZ‐O‐glucuronide, hydroxylated DBZ and danshensu. Danshensu, a hydrolysis product of DBZ, could further be transformed into 12 metabolites. The proposed method was confirmed to be a reliable and sensitive alternative for characterizing metabolic pathways of DBZ and providing valuable information on its druggability.  相似文献   
10.
In this paper, the existence and multiplicity of positive solutions is established for Schrödinger‐Poisson system of the form where 0 ∈ Ω is a smooth bounded domain in , , and λ > 0 is a real parameter. Combining with the variational method and Nehari manifold method, two positive solutions of the system are obtained.  相似文献   
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