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Chromatographia - We developed a simple, rapid, ecological RP-HPLC method for the estimation of Pitavastatin (PIT), Fenofibrate (FEN), and their impurities in a novel fixed dose combination. We... 相似文献
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Megan Douglass Sean Hopkins Rashmi Pandey Priya Singha Megan Norman Hitesh Handa 《Macromolecular bioscience》2021,21(1)
The novel use of nanofibers as a physical barrier between blood and medical devices has allowed for modifiable, innovative surface coatings on devices ordinarily plagued by thrombosis, delayed healing, and chronic infection. In this study, the nitric oxide (NO) donor S‐nitrosoglutathione (GSNO) is blended with the biodegradable polymers polyhydroxybutyrate (PHB) and polylactic acid (PLA) for the fabrication of hemocompatible, antibacterial nanofibers tailored for blood‐contacting applications. Stress/strain behavior of different concentrations of PHB and PLA is recorded to optimize the mechanical properties of the nanofibers. Nanofibers incorporated with different concentrations of GSNO (10, 15, 20 wt%) are evaluated based on their NO‐releasing kinetics. PLA/PHB + 20 wt% GSNO nanofibers display the greatest NO release over 72 h (0.4–1.5 × 10?10 mol mg?1 min?1). NO‐releasing fibers successfully reduce viable adhered bacterial counts by ≈80% after 24 h of exposure to Staphylococcus aureus. NO‐releasing nanofibers exposed to porcine plasma reduce platelet adhesion by 64.6% compared to control nanofibers. The nanofibers are found noncytotoxic (>95% viability) toward NIH/3T3 mouse fibroblasts, and 4′,6‐diamidino‐2‐phenylindole and phalloidin staining shows that fibroblasts cultured on NO‐releasing fibers have improved cellular adhesion and functionality. Therefore, these novel NO‐releasing nanofibers provide a safe antimicrobial and hemocompatible coating for blood‐contacting medical devices. 相似文献
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Rajarshi Roy Nilesh Mazumder Gundam Sandeep Kumar Hitesh Mamgain Uttam Kumar Ghorai Dipayan Sen Kalyan Kumar Chattopadhyay 《Journal of Raman spectroscopy : JRS》2016,47(7):845-851
To probe the intrinsic stress distribution in terms of spatial Raman shift (ω) and change in the phonon linewidth (Γ), here we analyze self‐assembled graphene oxide fibers (GOF) ‘Latin letters’ by confocal Raman spectroscopy. The self‐assembly of GOF ‘Latin letters’ has been explained through surface tension, π–π stacking, van der Waals interaction at the air–water interface and by systematic time‐dependent investigation using field emission scanning electron microscopy analysis. Intrinsic residual stress due to structural joints and bending is playing a distinct role affecting the E2g mode (G band) at and away from the physical interface of GOF segments with broadening of phonon linewidth, indicating prominent phonon softening. Linescan across an interface of the GOF ‘letters’ reveals Raman shift to lower wavenumber in all cases but more so in ‘Z’ fiber exhibiting a broader region. Furthermore, intrinsic stress homogeneity is observed for ‘G’ fiber distributed throughout its curvature with negligible shift corresponding to E2g mode vibration. This article demonstrates the significance of morphology in stress distribution across the self‐assembled and ‘smart‐integrable’ GOF ‘Latin letters’. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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The Soreq Applied Research Accelerator Facility (SARAF): Overview,research programs and future plans
Israel Mardor Ofer Aviv Marilena Avrigeanu Dan Berkovits Adi Dahan Timo Dickel Ilan Eliyahu Moshe Gai Inbal Gavish-Segev Shlomi Halfon Michael Hass Tsviki Hirsh Boaz Kaiser Daniel Kijel Arik Kreisel Yonatan Mishnayot Ish Mukul Ben Ohayon Michael Paul Amichay Perry Hitesh Rahangdale Jacob Rodnizki Guy Ron Revital Sasson-Zukran Asher Shor Ido Silverman Moshe Tessler Sergey Vaintraub Leo Weissman 《The European Physical Journal A - Hadrons and Nuclei》2018,54(5):91
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The polymeric coordination compounds have been synthesized using the dipotassium salt of N,N′‐di(carboxymethylene)terephthalaldehydediimine (K2SB1) or N,N′‐di(carboxyethylene)terephthalaldehydediimine (K2SB2) with manganese(II), cobalt(II), nickel(II), copper(II), zinc(II), and cadmium(II). The ligands have been characterized by 1H‐NMR, and 13C‐NMR spectra. The polychelates have been characterized by elemental analyses, magnetic measurements, thermogravimetric analyses, electronic spectra and infrared spectra. The coordination compounds are colored, and the central metal ions are octahedrally coordinated with two water molecules and the Schiff bases. The Schiff bases act as di‐negative tetradentate ligands, in which bonding occurs through two oxygen and two nitrogen atoms. The polymers are insoluble in all common organic solvents such as acetone, methanol, ethanol, N,N‐dimethylformamide and dimethylsulfoxide. 相似文献
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The hydrolysis reaction of O,O‐diethyl O‐p‐nitrophenylphosphate (Paraoxon) with the octanohydroxamate ion (OHA?) was studied in a cationic oil‐in‐water (O/W) microemulsion system over a pH range 7.5–12.0 at 300 K. The O/W systems are stabilized by using cationic surfactant, cetyltrimethylammonium bromide (CTAB), and n‐butanol as cosurfactants. In a microemulsion, the rate enhancement by OHA? is greater toward the cleavage of paraoxon than its spontaneous (2.1 × 107 s?1) hydrolysis. The kobs values for the reaction of paraoxon with OHA? were determined in different microemulsion compositions with varying chain length of alcohols (n‐butanol, n‐pentanol, n‐octanol, and n‐dodecanol) and alkanes (n‐hexane, n‐heptane, and n‐decane). The effects of water content, pH, and size of the oil pool have been discussed. 相似文献
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Bhanu Pemmaraju Hitesh K. Agarwal Donghoon Oh Karen W. Buckheit Robert W. Buckheit Jr. Rakesh Tiwari Keykavous Parang 《Tetrahedron letters》2014
A number of 5′-O-dicarboxylic fatty acyl monoester derivatives of 3′-azido-3′-deoxythymidine (zidovudine, AZT), 2′,3′-didehydro-2′,3′-dideoxythymidine (stavudine, d4T), and 3′-fluoro-3′-deoxythymidine (alovudine, FLT) were synthesized to improve the lipophilicity and potentially the cellular delivery of parent polar 2′,3′-dideoxynucleoside (ddN) analogs. The compounds were evaluated for their anti-HIV activity. Three different fatty acids with varying chain length of suberic acid (octanedioic acid), sebacic acid (decanedioic acid), and dodecanedioic acid were used for the conjugation with the nucleosides. The compounds were evaluated for anti-HIV activity and cytotoxicity. All dicarboxylic ester conjugates of nucleosides exhibited significantly higher anti-HIV activity than that of the corresponding parent nucleoside analogs. Among all the tested conjugates, 5′-O-suberate derivative of AZT (EC50 = 0.10 nM) was found to be the most potent compound and showed 80-fold higher anti-HIV activity than AZT without any significant toxicity (TC50 >500 nM). 相似文献
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