Determination of surface ζ‐potential and isoelectric point of carbon surfaces using tracer particle suspensions

Carbon materials are widely used in a range of applications from biomaterials to sensing and electronics. Many of these applications rely on the ability to control carbon/water interfacial properties, in particular, surface charge density. This work reports a study of the electrokinetic properties of amorphous carbon thin films as a function of pH and surface chemistry. Surface ζ‐potential (SZP) and isoelectric point were determined using the tracer particle method. Initially, the use of sulfonated and amine‐terminated latex bead suspensions as tracer particles for the determination of SZP of reference polymer surfaces was validated. The tracer particle method was then applied to the determination of SZP and isoelectric point of macroscopic carbon surfaces with different surface chemistry. Highly graphitic and sp³‐rich hydrogenated carbon surfaces were found to display negative SZP, as expected for hydrophobic surfaces. The isoelectric point of the most highly graphitic surface was found to be pH_iso = 3.7. Surface oxidation of these films resulted in a decrease of SZP at all pH values and in a downshift of pH_iso to values lower than 1.5, consistently with the presence of surface acidic groups arising from oxidation. Results indicate that the specific choice of acid/base chemistry for the tracer particles does not significantly affect either SZP or pH_iso determinations. These results show that the tracer particle method in combination with widely available latex beads as tracers can be applied for the determination of carbon SZP as a function of pH. Copyright © 2017 John Wiley & Sons, Ltd.     

Stochastic programming for nurse assignment

We present a brief overview of four phases of nurse planning. For the last phase, which assigns nurses to patients, a stochastic integer programming model is developed. A Benders’ decomposition approach is proposed to solve this problem, and a greedy algorithm is employed to solve the recourse subproblem. To improve the efficiency of the algorithm, we introduce sets of valid inequalities to strengthen a relaxed master problem. Computational results are provided based upon data from Baylor Regional Medical Center in Grapevine, Texas. Finally, areas of future research are discussed.     

Photoelectron spectra of cyclic aromatic ethers : The question of the mills-nixon effect

UV photoelectron spectra (UPS) of the cyclic aromatic ethers (1; R = H, n = 1, 2) are compared with each other and with those of non-cyclic ethers. The spectrum of the chroman (1; R = H, n = 2) is clearly distinguishable from those of all the other ethers. The differences in the spectra have been interpreted in terms of differing conjugative effects of oxygen and of “hyperconjugative” effects of methylene with the aromatic ring. These conclusions are supported by MO calculations. The bearing of these differing conjugative effects on reactivity of cyclic aromatic ethers is discussed and the conclusion reached that the orientational preferences customarily explained by the “Mills-Nixon effect” do not depend upon variation of bond lengths or bond angles in the aromatic ring but upon cross-conjugation effects in “Wheland” transition states.     

Copper and iron interactions with angiotensin-converting enzyme inhibitors. A study by fast-atom bombardment tandem mass spectrometry

Fast atom bombardment, combined with high-energy collision-induced tandem mass spectrometry, has been used to investigate gas-phase metal-ion interactions with captopril, enalaprilat and lisinopril, all angiotensin-converting enzyme inhibitors.Suggestions for the location of metal-binding sites are presented. For captopril, metal binding occurs most likely at both the sulphur and the nitrogen atom. For enalaprilat and lisinopril, binding preferably occurs at the amine nitrogen. Copyright 1999 John Wiley & Sons, Ltd.