Chloroform extract from the leaves of
Turraea vogelii Hook f. ex Benth demonstrated cytotoxic activity against a chronic myelogenous leukemia cell, K-562 with IC
50 of 14.27 μg/mL, while chloroform, ethyl acetate and methanol extracts from the stem of the plant inhibited K-562 cells growth with IC
50 of 19.50, 24.10 and 85.40 μg/mL respectively. Bioactive chloroform extract of
Turraea vogelii leaves affords two triterpenoids: oleana-12,15,20-trien-3β-ol
(1), and oleana-11,13-dien-3β,16α,28-triol
(2), with six fatty esters, ethyl hexaeicos-5-enoate
(3), 3-hydroxy-1,2,3-propanetriyltris(tetadecanoate)
(4), 1,2,3-propanetriyl(7Z,7′Z,7′′Z)tris(-7-hexadecenoate)
(5), 1,2,3-propanetriyl(5Z,5′Z,5′′Z)tris(-5-hexadecenoate)
(6), 1,2,3-propanetriyltris(octadecanoate)
(7), and 2β-hydroxymethyl tetraeicosanoate
(8). Tetradecane (
9), four fatty acids: hexadecanoic acid (
10), tetradecanoic acid (
11),
(Z)-9-eicosenoic acid
(12), and ethyl tetradec-7-enoate
(13) were isolated from chloroform extract of
Turraea vogelii stem. 1,2,3-propanetriyltris(heptadecanoate)
(14),
(Z)-9-octadecenoic acid
(15) and
(Z)-7-tetradecenoic acid
(16) were isolated from ethyl acetate extract while
(Z)-5-pentadecenoic acid
(17) was obtained from methanol extract of the plant stem. Compounds
1,
2,
5,
6,
11,
12,
15,
16 and
17 exhibited pronounced antiproliferative activity against K-562 cell lines.
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