基于反相位脉冲技术的生物组织谐波成像研究

理论及实验研究了反相位脉冲技术在生物组织二次谐波成像中的应用。结合有限振幅声波的非线性传播理论,从理论上证明了反相位脉冲技术可有效抑制基波信号,同时二次谐波信号增强两倍,轴向及径向声场的实验测量结果基波被抑制30～50dB,二次谐波提高6dB,与理论相符。建立了相应的成像系统,对若干生物离体组织进行了基于反相位脉冲相位技术的二次谐波成像,并与常规的基波及二次谐波图像对比,进一步证明了该技术能有效提高图像的对比度和清晰度。     

应用角谱方法研究聚焦声束在层状生物组织中的非线性声传播

应用角谱方法理论研究了聚焦声束在层状生物组织中的非线性传播特性，将声波分解为角谱，可计算垂直于声轴的任意平面的非线性声场。在圆形平面活塞聚焦换能器的焦区中插入多种生物组织样品，数值计算了样品内部及外部的二次谐波声场，并通过实验测量验证了理论方法的有效性。基于快速傅氏变换的角谱方法可直观地描述非线性声传播，对非线性声成像有指导作用。     

第十六届国际非线性声学会议在莫斯科市举行

第十六届国际非线性声学会议(InternationalSymposium on Nonlinear Acoustics,简称16thISNA)于2002年8月19日至23日在俄罗斯首都莫斯科市举行。来自全世界28个国家和地区约300人参加了会议,其中俄罗斯160人,美国32人,法国16人,日本11人,德国9人,英国7人,瑞典7人,….等等;中国代表有3人,他们是南京大学龚秀芬教授和王耀俊教授,江西吉安师范学院李化茂教授。ISNA是由国际非线性声学学术委员会主办的国际学术会议,每3年举行一次,自1968年以来已举办了16次,在声学和非线性声学领域具有很大的影响。本届会议由俄罗斯的莫斯科大学组织和承办。会议     

不可溶混合液体的非线性声参量

本文设不可溶流体的混合液的总体积为各组份体积之和,直接求导并计及各组份体积比随压力的变化,得到混合液等效非线性声参量(B/A)_ef与各组份体积比xi,它们的(B/A);及绝热压缩系数β_i的关系,并作了实验验证,实验与理论符合较好。     

反射式非线性声参量层析成像的研究

非线性声参量Ｂ／Ａ描述了有限振幅波在媒质中传播的非线性特性，有可能成为生物组织定征的新参量。本文提出了利用复合式换能器进行反射式的非线性参量Ｂ／Ａ层析成像的新方法。利用反射二次谐波的传播理论及有限振幅波插入取代法给出了计算机重建Ｂ／Ａ层析像的理论方法。对部分流体及生物组织进行了计算机模拟成像及实验研究，取得了较为满意的结果。     

圆锥面PVDF聚焦换能器的非线性声场理论及实验研究

圆锥面聚焦换能器可在超声成像中获得较好径向分辨率的同时提高探测深度.利用高斯声源函数叠加法来近似表示圆锥面聚焦声源的分布函数，结合近轴近似的KZK方程，得到了圆锥面聚焦换能器在损耗媒质中产生的基波、二次谐波声场的解析解.在实验上制作了PVDF圆锥面聚焦换能器，测量了圆锥面聚焦换能器的基波及二次谐波声场，实验结果和理论计算相符.     

Estimation of temperature elevation generated by ultrasonic irradiation in biological tissues using the thermal wave method

In most previous models,simulation of the temperature generation in tissue is based on the Pennes bio-heat transfer equation,which implies an instantaneous thermal energy deposition in the medium.Due to the long thermal relaxation time τ(20 s-30 s) in biological tissues,the actual temperature elevation during clinical treatments could be different from the value predicted by the Pennes bioheat equation.The thermal wave model of bio-heat transfer(TWMBT) defines a thermal relaxation time to describe the tissue heating from ultrasound exposure.In this paper,COMSOL Multiphysics 3.5a,a finite element method software package,is used to simulate the temperature response in tissues based on Pennes and TWMBT equations.We further discuss different factors in the bio-heat transfer model on the influence of the temperature rising and it is found that the temperature response in tissue under ultrasound exposure is a rising process with a declining rate.The thermal relaxation time inhibits the temperature elevation at the beginning of ultrasonic heating.Besides,thermal relaxation in TWMBT leads to lower temperature estimation than that based on Pennes equation during the same period of time.The blood flow carrying heat dominates most to the decline of temperature rising rate and the influence increases with temperature rising.On the contrary,heat diffusion,which can be described by thermal conductivity,has little effect on the temperature rising.     

Finite element modeling of acoustic scattering from an encapsulated microbubble near rigid boundary

This article proposes a finite element model(FEM) for predicting the acoustic scattering from an encapsulated microbubble near rigid boundary.The validity of the model is first examined by comparing the acoustic nonlinear response of a free microbubble with that obtained by the Church model.Then this model is used to investigate the effect of the rigid boundary on acoustic scattering signals from microbubble.The results indicate that the resonance frequency decreases while the oscillation amplitude increases as the microbubble approaches the rigid boundary.In addition,the fundamental component of the acoustic scattering signal is enhanced compared with that of the free microbubble.     

Difference-frequency ultrasound generation from microbubbles under dual-frequency excitation

The difference-frequency (DF) ultrasound generated by using parametric effect promises to improve detection depth owing to its low attenuation, which is beneficial for deep tissue imaging. With ultrasound contrast agents infusion, the harmonic components scattered from the microbubbles, including DF, can be generated due to the nonlinear vibration. A theoretical study on the DF generation from microbubbles under the dual-frequency excitation is proposed in formula based on the solution of the RPNNP equation. The optimisation of the DF generation is discussed associated with the applied acoustic pressure, frequency, and the microbubble size. Experiments are performed to validate the theoretical predictions by using a dual-frequency signal to excite microbubbles. Both the numerical and experimental results demonstrate that the optimised DF ultrasound can be achieved as the difference frequency is close to the resonance frequency of the microbubble and improve the contrast-to-tissue ratio in imaging.