首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   80162篇
  免费   428篇
  国内免费   593篇
化学   25665篇
晶体学   802篇
力学   6831篇
综合类   11篇
数学   32210篇
物理学   15664篇
  2023年   53篇
  2022年   47篇
  2021年   53篇
  2020年   67篇
  2019年   97篇
  2018年   10491篇
  2017年   10312篇
  2016年   6146篇
  2015年   945篇
  2014年   407篇
  2013年   469篇
  2012年   3951篇
  2011年   10706篇
  2010年   5755篇
  2009年   6159篇
  2008年   6716篇
  2007年   8865篇
  2006年   364篇
  2005年   1408篇
  2004年   1610篇
  2003年   2021篇
  2002年   1060篇
  2001年   277篇
  2000年   310篇
  1999年   198篇
  1998年   218篇
  1997年   172篇
  1996年   236篇
  1995年   135篇
  1994年   91篇
  1993年   111篇
  1992年   72篇
  1991年   78篇
  1990年   63篇
  1989年   66篇
  1988年   67篇
  1987年   65篇
  1986年   60篇
  1985年   52篇
  1984年   51篇
  1983年   40篇
  1982年   42篇
  1981年   40篇
  1980年   47篇
  1979年   46篇
  1914年   45篇
  1913年   40篇
  1912年   40篇
  1909年   41篇
  1908年   40篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Cancer is a global issue and a serious threat to human health, one approach to treatment is starvation therapy. Recently, three-dimensional (3D) bioprinted tumor tissue models have been developed; however, whether 3D bioprinted models are good for in vitro study of starvation therapy is unclear. In this study, we studied the state of cells with serum-free medium in both 3D bioprinted scaffold and 2D cell cultures and found that 3D bioprinted cancer cells (3D cells) were more tolerant to serum starvation than 2D cells in terms of cell viability, cell proliferation, and M2 macrophage polarization. Moreover, the ratio of LC3II/I, an index of autophagy, increased much more in 3D cells, and 3D cells showed more autophagosomes than 2D cells after serum starvation, which indicated that the autophagy levels were higher in 3D cells. These results suggested that 3D cells are more tolerant to serum starvation than 2D cells, and autophagy may play an important role in this process.  相似文献   
2.
多年来通常认为以吴方法为代表的几何定理机器证明的坐标法给出的证明不可读,或不是图灵意义下的类人解答.其实,只要对吴氏的算法做不多的改进,即将命题的结论多项式表示为其条件多项式的线性组合,就能获得不依赖于理论、算法和大量计算过程的恒等式明证.这样的恒等式可以转化为其他更简明且更有直观几何意义的点几何形式或向量及其他形式,从而获得多种证明方法.这也证明了点几何恒等式明证方法对等式型几何命题的普遍有效性.  相似文献   
3.
Zhao  X. H.  Yi  S. H.  Mi  Q.  Hu  Y. F.  Ding  H. L. 《Fluid Dynamics》2022,57(5):686-696
Fluid Dynamics - Both numerical methods and wind tunnel tests were used to reduce skin friction for a hypersonic body. A hypersonic cone was tested under three different free-stream flow...  相似文献   
4.
A nonlinear damage model based on the combination of deformation and hysteretic energy and its validation with experiments are presented. Also, a combination parameter is defined to consider the mutual effect of deformation and hysteretic energy for different types of components in different loading stages. Four reinforced concrete (RC) columns are simulated and analyzed using the nonlinear damage model. The results indicate that the damage evolution evaluated by the model agrees well with the experimental phenomenon. Furthermore, the seismic damage evolution of a six-story RC frame was analyzed, revealing four typical failure modes according to the interstory drift distribution of the structure; the damage values calculated using the nonlinear damage model agree well with the four typical failure modes.  相似文献   
5.
Measuring angles in the Euclidean plane is a well-known topic, but for general normed planes there exists a variety of different concepts. These can be of a special kind, e.g. also preserving special orthogonality types. But these concepts are no angle measures in the sense of measure theory since they are not additive. This motivates us to define a new angle measure for normed planes that is in fact a measure in the sense of measure theory. Furthermore, we look at related types of rotation and reflection.  相似文献   
6.
We analyze isolated resonance curves (IRCs) in single-degree-of-freedom systems possessing nonlinear damping. Through the combination of singularity theory and the averaging method, the onset and merging of IRCs, which coincide to isola and simple bifurcation singularities, respectively, can be analytically predicted. Numerical simulations confirm the accuracy of the analytical developments. Another important finding of this paper is that we unveil a geometrical connection between the topology of the damping force and IRCs. Specifically, we demonstrate that extremas and zeros of the damping force correspond to the appearance and merging of IRCs. Considering a damping force possessing several minima and maxima confirms the general validity of the analytical result. It also evidences a very complex scenario for which different IRCs are created, co-exist and then merge together to form a super IRC which eventually merges with the main resonance peak.  相似文献   
7.
The effect of surface tension on laminar natural convection in a vertical cylindrical cavity filled with a weak evaporating liquid has been analyzed numerically. The cylindrical enclosure is insulated at the bottom, heated by a constant heat flux from the side, and cooled by a non-uniform evaporative heat flux from the top free surface having temperature-dependent surface tension. Governing equations with corresponding boundary conditions formulated in dimensionless stream function, vorticity, and temperature have been solved by finite difference method of the second-order accuracy. The influence of Rayleigh number, Marangoni number, and aspect ratio on the liquid flow and heat transfer has been studied. Obtained results have revealed that the heat transfer rate at free surface decreases with Marangoni number and increases with Rayleigh number, while the average temperature inside the cavity has an opposite behavior; namely, it growths with Marangoni number and reduces with Rayleigh number.  相似文献   
8.
Recently, the authors have focused on the shear behavior of interface between granular soil body and very rough surface of moving bounding structure. For this purpose, they have used finite element method and a micro-polar elasto-plastic continuum model. They have shown that the boundary conditions assumed along the interface have strong influences on the soil behavior. While in the previous studies, only very rough bounding interfaces have been taken into account, the present investigation focuses on the rough, medium rough and relatively smooth interfaces. In this regard, plane monotonic shearing of an infinite extended narrow granular soil layer is simulated under constant vertical pressure and free dilatancy. The soil layer is located between two parallel rigid boundaries of different surface roughness values. Particular attention is paid to the effect of surface roughness of top and bottom boundaries on the shear behavior of granular soil layer. It is shown that the interaction between roughness of bounding structure surface and the rotation resistance of bounding grains can be modeled in a reasonable manner through considered Cosserat boundary conditions. The influence of surface roughness is investigated on the soil shear strength mobilized along the interface as well as on the location and evolution of shear localization formed within the layer. The obtained numerical results have been qualitatively compared with experimental observations as well as DEM simulations, and acceptable agreement is shown.  相似文献   
9.
By introducing the mechanical motion into the confined etchant layer technique (CELT), we have developed a promising ultra-precision machining method, termed as electrochemical mechanical micromachining (ECMM), for producing both regular and irregular three dimensional (3D) microstructures. It was found that there was a dramatic coupling effect between the confined etching process and the slow-rate mechanical motion because of the concentration distribution of electrogenerated etchant caused by the latter. In this article, the coupling effect was investigated systemically by comparing the etchant diffusion, etching depths and profiles in the non-confined and confined machining modes. A two-dimensional (2D) numerical simulation model was proposed to analyze the diffusion variations during the ECMM process, which is well verified by the machining experiments. The results showed that, in the confined machining mode, both the machining resolution and the perpendicularity tolerance of side faces were improved effectively. Furthermore, the theoretical modeling and numerical simulations were proved valuable to optimize the technical parameters of the ECMM process.  相似文献   
10.
Risperidone (RIS), one of the typical antipsychotics drugs, originally approved to be used for the mental illness treatment, especially schizophrenia, bipolar disorder, autism and major depression. In the present study, different carbon nanostructures including functionalized multi-walled carbon nanotubes (F-MWCNTs), carbon nanoparticles, nanodiamond-graphite and reduced graphene oxide were employed for modification of the surface of glassy carbon electrode (GCE) for ultrasensitive detection of RIS. The most significant increase in the anodic peak current of RIS was observed on F-MWCNTs-modified electrode (compared to the other modified electrodes and bare GCE). The influence of different experimental parameters such as pH of the buffered solutions, the amount of the modifier and time and potential of the accumulation was optimized by monitoring the LSV responses toward RIS for the selected modified electrode. A wide linear dynamic range of 0.04–7 µM with a low detection limit of 12 nM was obtained. The results exhibit an acceptable performance of the proposed electrode for determination of RIS in the pharmaceutical and clinical preparations.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号