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曾溢滔 《中国科学A辑》1975,18(4):419-430
正常人的血红蛋白有血红蛋白A(Hb A),血红蛋白A2(Hb A2)和血红蛋白F(Hb F)。各血红蛋白由不同肽链构成,各种肽链又严格地按一定的氨基酸排列顺序,任何肽链发生变异而形成的新的血红蛋白就称为异常血红蛋白。近年来在国内发现了两种血红蛋白MHb MShanghai—1,Hb MShanghai—2和两种不稳定血红蛋白HbShanghai—1,HbShanghai—2,其中HbShanghai—2的先证者认为是不稳定血红蛋白基因和β-地中海贫血基因的双杂合子。本文是对这四种异常血红蛋白生化分析和遗传研究的总结。另外,报道了α-地中海贫血症的两个家系,发现患者血中除含有血红蛋白Bart''s和血红蛋白H外,还有微量的其他异常血红蛋白成分,据此,对α-地中海贫血症的遗传提出一个新的假说。  相似文献
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公司所属行业是陷入财务困境的一个重要的影响因素,本文主要运用Cox模型衡量不同行业的财务困境风险关系。我们以我国A股制造业上市公司为研究对象,选取制造业中样本量最大的两个次级行业:机械、设备、仪表行业以及石油、化学、塑料行业,以"月"作为生存时间基本单位,选取8个财务指标和一个行业虚拟变量进行实证研究。实证结果表明机械、设备、仪表行业陷入财务困境的风险为石油、化学、塑料行业的0.469倍,并且显著影响这两个行业的公司陷入财务困境的财务指标也不相同,表明研究财务困境考虑行业的重要性;稳健性检验表明这些结论具有可靠性。  相似文献
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Cost effectiveness is central to the air freight forwarders. In this work, we study how an air freight forwarder should plan its cargo loading in order to minimize the total freight cost given a limited number of rented containers. To solve the problem efficiently for practical implementation, we propose a new large-scale neighborhood search heuristic. The proposed large-scale neighborhood relaxes the subset-disjoint restriction made in the existing literature; the relaxation risks a possibility of infeasible exchanges while at the same time it avoids the potentially large amount of checking effort required to enforce the subset-disjoint restriction. An efficient procedure is then used to search for improvement in the neighborhood. We have also proposed a subproblem to address the difficulties caused by the fixed charges. The compromised large-scale neighborhood (CLSN) search heuristic has shown stably superior performance when compared with the traditional large-scale neighborhood search and the mixed integer programming model.  相似文献
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In this paper, we address the route planning problem in fourth party logistics (4PL). The problem calls for the selection of the logistics companies by a 4PL provider to optimize the routes of delivering goods through a transportation network. The concept of 4PL emerged in response to the shortfall in services capabilities of traditional third party logistics and has been proven to be capable of integrating logistics resources in order to fulfill complex transportation demands. A mixed-integer programming model is established for the planning problem with setup cost and edge cost discount policies which are commonly seen in practice. We propose a column generation approach combined with graph search heuristic to efficiently solve the problem. The good performance in terms of the solution quality and computational efficiency of our approach is shown through extensive numerical experiments on various scales of test instances. Impacts of cost policies on routing decision are also investigated and managerial insights are drawn.  相似文献
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Balinsky–Novikov superalgebras were introduced by Balinsky for constructing super-Virasoro type Lie superalgebras. In this paper, we give sufficient and necessary conditions for a Lie superalgebra generalized by a Balinsky–Novikov superalgebra with dimension 2|2 to be a quadratic Lie superalgebra.  相似文献
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