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排序方式: 共有251条查询结果,搜索用时 46 毫秒
1.
Eckhard Flter Till Wettlaufer Valentina Conty Maria Scharfe 《Molecules (Basel, Switzerland)》2021,26(6)
Oleogels or, more precisely, non-triglyceride structured lipid phases have been researched excessively in the last decade. Yet, no comprehensive knowledge base has emerged, allowing technology elevation from the laboratory bench into the industrial food application. That is partly due to insufficient characterization of the structuring systems studied. Examining a single composition decided upon by arbitrary methods does not stimulate progress in the research and technology area. A framework that gives much better guidance to product applications can easily be derived. For example, the incremental structure contribution concept is advocated as a parameter to compare the potency of structuring systems. These can straightforwardly be determined by combining solubility data and structural measurements in the recommended manner. The current method to determine the oil-binding capacity suffers from reproducibility and relevance. A newly developed method is suggested to overcome these shortcomings. The recommended new characterization of oleogels should contribute to a more comprehensive knowledge base necessary for product innovations. 相似文献
2.
Lars J. Wesenberg Erika Diehl Till J. B. Zähringer Carolin Dörr Dr. Dieter Schollmeyer Dr. Akihiro Shimizu Prof. Dr. Jun-ichi Yoshida Prof. Dr. Ute A. Hellmich Prof. Dr. Siegfried R. Waldvogel 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(72):17574-17580
The efficient production of many medicinally or synthetically important starting materials suffers from wasteful or toxic precursors for the synthesis. In particular, the aromatic non-protected primary amine function represents a versatile synthetic precursor, but its synthesis typically requires toxic oxidizing agents and transition metal catalysts. The twofold electrochemical amination of activated benzene derivatives via Zincke intermediates provides an alternative sustainable strategy for the formation of new C−N bonds of high synthetic value. As a proof of concept, we use our approach to generate a benzoxazinone scaffold that gained attention as a starting structure against castrate-resistant prostate cancer. Further improvement of the structure led to significantly increased cancer cell line toxicity. Thus, exploiting environmentally benign electrooxidation, we present a new versatile and powerful method based on direct C−H activation that is applicable for example the production of medicinally relevant compounds. 相似文献
3.
4.
Kerim Isik Yoshinori Yoshida Lin Chen Till Clausmeyer A. Erman Tekkaya 《Comptes Rendus Mecanique》2018,346(8):770-778
This paper presents a methodology to model a blanking process using a continuum mechanical damage model. A variant of the Lemaitre model, in which the quasi-unilateral conditions are taken into consideration to modify the damage behavior under compressive stress states, is selected as material model. S45C high-carbon steel is analyzed experimentally. To characterize the damage behavior of the material, notched round bar tensile tests with three different notch radii (6 mm, 10 mm, and 20 mm) using image analysis are performed. Using digital image processing, the strain at the deformation zone can be computed for the load–strain curves. Those curves are used as an objective function to determine the parameters of the Lemaitre damage model. The experimental results are compared with the results of the FE analysis of the tensile test. The identified model parameters are used in numerical investigations of axisymmetric blanking. The effect of the model's extension to quasi-unilateral damage evolution is discussed. The crack progress in high-carbon steel sheet during blanking and the final sheared part morphology are predicted and compared with the experimental results. Sheared surface and burr height obtained by the analysis coincide with the results of the blanking experiment. 相似文献
5.
Johannes C. B. Dietschreit Annika Wagner T. Anh Le Philipp Klein Prof. Dr. Hermann Schindelin Prof. Dr. Till Opatz Prof. Dr. Bernd Engels Prof. Dr. Ute A. Hellmich Prof. Dr. Christian Ochsenfeld 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(31):12769-12773
The absence of fluorine from most biomolecules renders it an excellent probe for NMR spectroscopy to monitor inhibitor–protein interactions. However, predicting the binding mode of a fluorinated ligand from a chemical shift (or vice versa) has been challenging due to the high electron density of the fluorine atom. Nonetheless, reliable 19F chemical-shift predictions to deduce ligand-binding modes hold great potential for in silico drug design. Herein, we present a systematic QM/MM study to predict the 19F NMR chemical shifts of a covalently bound fluorinated inhibitor to the essential oxidoreductase tryparedoxin (Tpx) from African trypanosomes, the causative agent of African sleeping sickness. We include many protein–inhibitor conformations as well as monomeric and dimeric inhibitor–protein complexes, thus rendering it the largest computational study on chemical shifts of 19F nuclei in a biological context to date. Our predicted shifts agree well with those obtained experimentally and pave the way for future work in this area. 相似文献
6.
Cem B. Yildiz Kinga I. Leszczyska Sandra Gonzlez‐Gallardo Michael Zimmer Akin Azizoglu Till Biskup Christopher W. M. Kay Volker Huch Henry S. Rzepa David Scheschkewitz 《Angewandte Chemie (International ed. in English)》2020,59(35):15087-15092
Main group analogues of cyclobutane‐1,3‐diyls are fascinating due to their unique reactivity and electronic properties. So far only heteronuclear examples have been isolated. Here we report the isolation and characterization of all‐silicon 1,3‐cyclobutanediyls as stable closed‐shell singlet species from the reversible reactions of cyclotrisilene c‐Si3Tip4 (Tip=2,4,6‐triisopropylphenyl) with the N‐heterocyclic silylenes c‐[(CR2CH2)(NtBu)2]Si: (R=H or methyl) with saturated backbones. At elevated temperatures, tetrasilacyclobutenes are obtained from these equilibrium mixtures. The corresponding reaction with the unsaturated N‐heterocyclic silylene c‐(CH)2(NtBu)2Si: proceeds directly to the corresponding tetrasilacyclobutene without detection of the assumed 1,3‐cyclobutanediyl intermediate. 相似文献
7.
Differential infrared thermography (DIT) was investigated and applied for the detection of unsteady boundary layer transition locations on a pitching airfoil and on a rotating blade under cyclic pitch. DIT is based on image intensity differences between two successively recorded infrared images. The images were recorded with a high framing rate infrared camera. A pitching NACA0012 airfoil served as the first test object. The recorded images were used in order to investigate and to further improve evaluation strategies for periodically moving boundary layer transition lines. The measurement results are compared with the results of unsteady CFD simulations based on the DLR-TAU code. DIT was then used for the first time for the optical measurement of unsteady transition locations on helicopter rotor blade models under cyclic pitch and rotation. Image de-rotation for tracking the blade was employed using a rotating mirror to increase exposure time without causing motion blur. The paper describes the challenges that occurred during the recording and evaluation of the data in detail. However, the results were found to be encouraging to further improve the method toward the measurement of unsteady boundary layer transition lines on helicopter rotor models in forward flight. 相似文献
8.
Nicola Otto Prof. Dr. Till Opatz 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(41):13064-13077
Owing to their various modes of reactivity, α‐aminonitriles represent versatile building blocks for the construction of a wide range of nitrogen heterocycles. The present Concept article focuses on synthetic methodologies using their bifunctional nature which is the basis of their reactivity as α‐amino carbanions and as iminium ions. Reactions exclusively taking place on either the amine or on the nitrile moiety will not be considered. 相似文献
9.
Cover Picture: Absolute Configuration from Different Multifragmentation Pathways in Light‐Induced Coulomb Explosion Imaging (ChemPhysChem 16/2016) 下载免费PDF全文
Dr. Martin Pitzer Gregor Kastirke Dr. Maksim Kunitski Dr. Till Jahnke Dr. Tobias Bauer Christoph Goihl Florian Trinter Carl Schober Kevin Henrichs Jasper Becht Stefan Zeller Helena Gassert Markus Waitz Andreas Kuhlins Hendrik Sann Felix Sturm Florian Wiegandt Dr. Robert Wallauer Dr. Lothar Ph. H. Schmidt Allan S. Johnson Manuel Mazenauer Benjamin Spenger Sabrina Marquardt Sebastian Marquardt Prof. Dr. Horst Schmidt‐Böcking Prof. Dr. Jürgen Stohner Prof. Dr. Reinhard Dörner Dr. Markus Schöffler Prof. Dr. Robert Berger 《Chemphyschem》2016,17(16):2448-2448
10.
Till Heinemann Matthias Springer Hermann Lienhart Stefan Kniesburges Carsten Othmer Stefan Becker 《Experiments in fluids》2014,55(5):1-11
Lift and drag of a passenger car are strongly influenced by the flow field around its rear end. The bluff body geometry produces a detached, transient flow which induces fluctuating forces on the body, affecting the rear axle, which may distress dynamic stability and comfort significantly. The investigations presented here deal with a 1:4 scale model of a simplified test car geometry that produces fluctuating lift and drag due to its strongly rounded rear geometry. To examine the influence of active flow control on this behavior, steady air jets were realized to exhaust from thin slots across the rear in three different configurations. Investigations were performed at $Re = 2.1 \times 10^{6}$ and included the capturing of effective integral lift and drag, velocity measurements in the surrounding flow field with Laser Doppler Anemometry, surface pressure measurements and surface oil flow visualization on the rear. The flow field was found to be dominated by two longitudinal vortices, developing from the detachment of the flow at the upper C-pillar positions, and a recirculating, transverse vortex above the rear window. With an air jet emerging from a slot across the surface right below the rear window section, tangentially directed upstream toward the roof section, total lift could be reduced by more than 7 %, with rear axle lift reduction of about 5 % and negligible drag affection ( $<$ 1 %). 相似文献