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1.
P. Lugli C. Erlen A. Pecchia F. Brunetti L. Latessa A. Bolognesi G. Csaba G. Scarpa A. di Carlo 《Applied Physics A: Materials Science & Processing》2007,87(3):593-598
Molecular devices have lately attracted increased attention due to some appealing features such as their low production cost,
flexibility in the substrate choice, possibility of large area deployment, and possibly higher integration capabilities. Starting
from a series of results obtained from our groups, we critically review the state-of-the-art in the field of simulation of
organic and molecular systems, by analyzing and comparing existing approaches, and looking at the open problems and possible
solutions and future developments.
PACS 72.80.Le 相似文献
2.
Studies on the encapsulation of diclofenac in small unilamellar liposomes of soya phosphatidylcholine 总被引:5,自引:0,他引:5
Lopes LB Scarpa MV Silva GV Rodrigues DC Santilli CV Oliveira AG 《Colloids and surfaces. B, Biointerfaces》2004,39(4):151-158
The encapsulation of acid (AD) and sodium diclofenac (SD) in small unilamellar liposomes (SUV) as well as the interactions of the drug with the bilayer was studied. SUV was prepared by sonication from multilamellar liposomes containing soya phosphatidylcholine and diclofenac at various proportions. The size distribution obtained from dynamic light scattering showed that the incorporation of SD decreases significantly the size of the liposomes suggesting that the drug interacts with the bilayer of the liposomes. This size decrease is related with the phase transition of liposomes to mixed micelar solution. The encapsulation of the hydrophilic dye indocyanine green in the aqueous compartment of liposomes showed that the rate of captured dye decreases with SD concentration suggesting the transition of liposomes to mixed micelles. The (31)P NMR analysis indicates that SD interacts with the phosphate of phosphatidylcholine head groups. A schematic model for interaction of SD with phosphatidylcholine of the liposomes in which the diclofenac anion interacts with the ammonium group of the phospholipid and the dichlorophenyl ring occupies a more internal site of bilayer near phosphate group was proposed. 相似文献
3.
Souza SM Oliveira ON Scarpa MV Oliveira AG 《Colloids and surfaces. B, Biointerfaces》2004,36(1):13-17
The interaction of diclofenac sodium (SD) with soya phosphatidylcholine (SPC) has been studied with floating Langmuir monolayers and liposomes. SD was either introduced into the subphase of SPC monolayers or co-spread with SPC on an aqueous subphase. In both cases, SD caused the surface pressure isotherm to become more expanded, thus demonstrating the affinity between SD and SPC. The incorporation of SD caused SPC liposomes to have a decreased diameter according to light scattering experiments. When SPC liposomes were injected into an aqueous subphase, their destruction yielding surface-active monomers could be monitored by changes in surface pressure. SD-loaded liposomes displayed a much faster kinetics when the surface density of surface-active monomers was plotted against time, with rate constants increasing significantly with the SD concentration. The kinetic profile can be quantitatively analyzed by plotting ln[1 - (gamma/gamma infinity)] versus t1/2. 相似文献
4.
D. Scarpa L. Biasetto S. Corradetti M. Manzolaro A. Andrighetto S. Carturan G. Prete P. Zanonato D. W. Stracener 《The European Physical Journal A - Hadrons and Nuclei》2011,47(3):32
In the framework of the R&D program for the SPES (Selective Production of Exotic Species) project of the Istituto Nazionale
di Fisica Nucleare (INFN), production yields of neutron-rich isotopes have been measured at the Holifield Radioactive Ion
Beam Facility (HRIBF, Oak Ridge National Laboratory, USA). This experiment makes use of the multi-foil SPES target prototype
composed of 7 uranium carbide discs, with excess of graphite (ratio C/U = 4 . 77 isotopes of medium mass (between 72 and 141amu), produced via proton-induced fission of uranium using a 40MeV proton
beam, have been collected and analyzed for the target heated at 2000 ° C target temperature. 相似文献
5.
Chorilli M Prestes PS Rigon RB Leonardi GR Chiavacci LA Sarmento VH Oliveira AG Scarpa MV 《Colloids and surfaces. B, Biointerfaces》2011,85(2):265-188
Carrier systems for lipophilic drugs, such as the liquid crystalline systems (LCS) have been extensively studied to improve effect and selectivity. Retinyl palmitate (RP) is widely used in pharmaceutical and cosmetics products to improve the skin elasticity. The aim of this study was the development, characterization and the in vivo effectiveness of RP in non-ionic LCS structures. LCS containing polyether functional siloxane as oil phase, silicon glycol copolymer as surfactant and water in the ratio 30:10:60, with and without RP were studied. The results of the polarized light microscopy, small-angle X-ray scattering and rheology analysis indicated the presence of typical LCS structures with lamellar arrangement. Regardless of the presence of RP, the rheological studies showed the pseudo plastic behavior of the systems. However, highest hysteresis area was verified when comparing the system in the presence and in the absence of RP. Stability study SAXS monitored, carried out up to 30 days in various storage temperature conditions (25±2 °C, 37±2 °C and 5±2 °C) demonstrated the great structural stability of the LCS systems. The in vivo effectiveness analysis suggests that the RP-loaded LCS provided a significant reduction of the orbicular wrinkles in human volunteers (P=0.048). 相似文献
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7.
Elena Froner Roberta Adamo Zeno Gaburro Benno Margesin Lorenzo Pavesi Adelio Rigo Marina Scarpa 《Journal of nanoparticle research》2006,8(6):1071-1074
Aqueous solutions of silicon nanocrystals have been obtained, by sonication, from porous Si (p-Si) aged in air for various times. The photoluminescence of these solutions changes with the aging time of p-Si. These changes correlate with nanocrystal core dimensions, i.e. with the oxidation of the nanocrystals. Infrared spectra show that the reaction with water depends on the age of the starting p-Si sample, since the native superficial oxide layer on p-Si inhibits these reactions. 相似文献
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10.
A column‐switching HPLC‐MS/MS method for mucopolysaccharidosis type I analysis in a multiplex assay for the simultaneous newborn screening of six lysosomal storage disorders 下载免费PDF全文
Antonina Gucciardi Elisa Legnini Iole Maria Di Gangi Carlo Corbetta Rosella Tomanin Maurizio Scarpa Giuseppe Giordano 《Biomedical chromatography : BMC》2014,28(8):1131-1139
Lysosomal storage disorders comprise a group of rare genetic diseases in which a deficit of specific hydrolases leads to the storage of undegraded substrates in lysosomes. Impaired enzyme activities can be assessed by MS/MS quantification of the reaction products obtained after incubation with specific substrates. In this study, a column‐switching HPLC‐MS/MS method for multiplex screening in dried blood spot of the lysosomal enzymes activities was developed. Mucopolysaccharidosis type I, Fabry, Gaucher, Krabbe, Niemann–Pick A/B and Pompe diseases were simultaneously assayed. Dried blood spots were incubated with substrates and internal standards; thereafter, supernatants were collected with minor manipulations. Samples were injected, trapped into an online perfusion column and, by a six‐port valve, switched online through the C18 analytical column to perform separation of metabolites followed by MS/MS analysis. A total of 1136 de‐identified newborn screening samples were analyzed to determine references for enzymes activity values. As positive controls, we analyzed dried blood spots from three patients with Pompe, one with Fabry, one with Krabbe disease and two with MPS I, and in all cases the enzyme activities were below the cutoff values measured for newborns, except for an MPS I patient after successful hematopoietic stem cell transplantation. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献