高效液相色谱-四极杆/静电场轨道阱高分辨质谱法快速分析三子散的入血成分及代谢产物

蒙药三子散由诃子、川楝子、栀子3味药材等比例组成,其临床用药主要采用口服给药方式,药物在体内的吸收、分布、代谢、排泄过程与药物发挥药理作用和疗效的产生密切相关,因此考察灌胃给药后的入血成分有助于阐明三子散的药效物质基础。研究采用血清药物化学研究思路,将Wistar大鼠分成空白组和给药组,给药组给予三子散水提物,腹主动脉取血,离心制备血清样品,采用高效液相色谱-四极杆/静电场轨道阱高分辨质谱(HPLC-Q/Orbitrap HRMS),在SHIMADZU GIST C₁₈色谱柱(150 mm×4.6 mm, 5 μm)上进行色谱分离;以甲醇和0.1%(v/v)甲酸水溶液为流动相进行梯度洗脱,柱温30 ℃,流速0.5 mL/min,进样量10 μL,采用加热电喷雾电离(HESI)源,正、负离子同时扫描。通过比对三子散含药血清和空白血清的图谱差异,查阅数据库、各类成分体内代谢途径、三子散成分的相关文献,采用Xcalibur 3.0软件进行峰提取、峰匹配等质谱数据处理,结合Compound Discover 3.0软件对化合物代谢途径的预测分析和裂解规律的推断,解析三子散水提液经大鼠灌胃后血清中的原型成分和代谢产物。结果表明,在给药大鼠血清样品中鉴定出55种入血成分,其中41种原型成分,14种代谢产物。入血的原型成分主要为鞣质类、环烯醚萜类和小分子酚酸类。该研究较为全面地阐释了三子散水提液在大鼠血中的移行成分,有助于揭示三子散的药效物质基础,为该药的临床应用提供参考。     

Gd~(3+)掺杂浓度对NaErF_4∶Yb纳米晶上转换荧光性能的影响

采用温和的溶剂热法制备较强红光发射的NaErF4∶Yb,Gd上转换纳米晶,控制Gd~(3+)的掺杂浓度实现了晶相和尺寸可控以及上转换荧光的增强。X射线衍射谱(XRD)、透射电子显微镜图像(TEM)和上转换发射光谱结果分析表明,Gd~(3+)掺杂可以有效地促进NaErF_4纳米晶的晶相由立方相向六角相转变,并且减小纳米粒子的尺寸。随着Gd~(3+)掺杂浓度的上升,上转换荧光强度明显增大。当Gd~(3+)摩尔分数为25%时,样品的上转换荧光强度达到最大。同时,研究了在980 nm近红外激光激发下,Yb~(3+)与Er~(3+)间有效的能量传递以及上转换发光机制。     

Remarks on the Regularity to 3-D Ideal Magnetohydrodynamic Equations

In this paper we are interested in the sufficient conditions which guarantee the regularityof solutions of 3-D ideal magnetohydrodynamic equations in the arbitrary time interval [0,T].Fivesufficient conditions are given.Our results are motivated by two main ideas:one is to control theaccumulation of vorticity alone;the other is to generalize the corresponding geometric conditions of3-D Euler equations to 3-D ideal magnetohydrodynamic equations.     

EXISTENCE OF WEAK SOLUTIONS OF 2－D EULER EQUATIONS WITH INITIAL VORTICITY ω_0∈E（log~＋L）~α（α＞0）

ＥＸＩＳＴＥＮＣＥＯＦＷＥＡＫＳＯＬＵＴＩＯＮＳＯＦ２－ＤＥＵＬＥＲＥＱＵＡＴＩＯＮＳＷＩＴＨＩＮＩＴＩＡＬＶＯＲＴＩＣＩＴＹω＿０∈Ｅ（ｌｏｇ￣＋Ｌ）￣α（α＞０）ＪＩＵＱＵＡＮＳＥＮ（ＩｎｓｔｉｔｕｔｅＯｆＡｐｐｌｉｅｄＭａｔｈｅｍａｔｉｃｓ，ｔ...     

4,4′-二乙炔二苯甲烷与苯乙炔的共聚及共聚物的表征研究

 本文做了4,4′-二乙炔二苯甲烷的本体热均聚和催化均聚,并用(Ph₃P)₂PdCl₂为催化剂做了4,4′-二乙炔二苯甲烷与苯乙炔的共聚,对均聚和共聚物中的不溶不熔组分测定了密度、溶胀度、Huggins参数以及交联点间的平均分子量M_c。实验表明,该交联聚合物的最良溶剂是四氢呋喃,溶度参数为9.9ca1^0.5。cm^-1.5,当用四氢呋喃为溶剂时的Huggins参数为0.34,并且在单体摩尔比中4,4′-二乙炔二苯甲烷用量越多,溶胀度越小,交联度越大。红外光谱分析表明,所有均聚及共聚物都为反式结构。     

关于二维Euler方程解的存在唯一性的一个附注

在局部存在唯一性的基础上,本文证明了当ω０ ∈Ｌ（２,１） 及ｕ０ ∈Ｃｒ 时二维Ｅｕｌｅｒ方程解的整体存在唯一性．这里Ｌ（２,１） 是Ｌｏｒｅｎｔｚ空间, Ｃｒ 是Ｈ氹ｌｄｅｒ空间     

4,4′-二乙炔二苯甲烷与苯乙炔的共聚及共聚物的表征研究

本文做了4,4′-二乙炔二苯甲烷的本体热均聚和催化均聚,并用(Ph_3P)_2PdCl_2为催化剂做了4,4′-二乙炔二苯甲烷与苯乙炔的共聚,对均聚和共聚物中的不溶不熔组分测定了密度、溶胀度、Huggins参数以及交联点间的平均分子量(?)_c。实验表明,该交联聚合物的最良溶剂是四氢呋喃,溶度参数为9.9ca1~0.5。cm~(-1.5),当用四氢呋喃为溶剂时的Huggins参数为0.34,并且在单体摩尔比中4,4′-二乙炔二苯甲烷用量越多,溶胀度越小,交联度越大。红外光谱分析表明,所有均聚及共聚物都为反式结构。     

Existence of Weak Solutions of Two-dimensional Euler Equations with Initial Vorticity in Lorentz Space L （2,1） （ R^2）

Some estimates on 2-D Euler equations are given when initial vorticity ω0 belongs to a Lorentz space L(2, 1). Then based on these estimates, it is proved that there exist global weak solutions of two dimensional Euler equations when ωo ∈ L(2, 1).     

On strong convergence to 3-D axisymmetric vortex sheets

We consider the 3-D axisymmetric incompressible Euler equations without swirls with vortex-sheets initial data. It is proved that the approximate solutions, generated by smoothing the initial data, converge strongly in provided that they have strong convergence in the region away from the symmetry axis. This implies that if there would appear singularity or energy lost in the process of limit for the approximate solutions, it then must happen in the region away from the symmetry axis. There is no restriction on the signs of initial vorticity here. In order to exclude the possible concentrations on the symmetry axis, we use the special structure of the equations for axisymmetric flows and careful choice of test functions.     

Global well‐posedness of the compressible Euler with damping in Besov spaces

In this paper, we consider the Cauchy problems for compressible Euler equations with damping. In terms of the Littlewood–Paley decomposition and Bony's para‐product formula, we prove the global existence, uniqueness and asymptotic behavior of the solution in the critical Besov space comparing with previous results. Copyright © 2012 John Wiley & Sons, Ltd.