全文获取类型
收费全文 | 502篇 |
免费 | 5篇 |
国内免费 | 14篇 |
专业分类
化学 | 212篇 |
晶体学 | 1篇 |
力学 | 4篇 |
数学 | 158篇 |
物理学 | 146篇 |
出版年
2019年 | 6篇 |
2018年 | 7篇 |
2017年 | 5篇 |
2016年 | 11篇 |
2015年 | 12篇 |
2014年 | 13篇 |
2013年 | 25篇 |
2012年 | 20篇 |
2011年 | 13篇 |
2010年 | 10篇 |
2008年 | 20篇 |
2007年 | 9篇 |
2006年 | 8篇 |
2004年 | 14篇 |
2003年 | 11篇 |
2002年 | 7篇 |
2001年 | 15篇 |
2000年 | 8篇 |
1999年 | 8篇 |
1998年 | 10篇 |
1997年 | 11篇 |
1996年 | 7篇 |
1995年 | 7篇 |
1994年 | 11篇 |
1993年 | 6篇 |
1992年 | 13篇 |
1991年 | 7篇 |
1990年 | 6篇 |
1988年 | 8篇 |
1987年 | 5篇 |
1985年 | 7篇 |
1983年 | 7篇 |
1980年 | 6篇 |
1978年 | 6篇 |
1977年 | 9篇 |
1976年 | 5篇 |
1974年 | 6篇 |
1973年 | 8篇 |
1972年 | 7篇 |
1971年 | 5篇 |
1968年 | 5篇 |
1967年 | 5篇 |
1935年 | 5篇 |
1933年 | 6篇 |
1927年 | 5篇 |
1926年 | 5篇 |
1924年 | 6篇 |
1920年 | 5篇 |
1911年 | 5篇 |
1908年 | 5篇 |
排序方式: 共有521条查询结果,搜索用时 15 毫秒
1.
Tobramycin and Nebramine as Pseudo‐oligosaccharide Scaffolds for the Development of Antimicrobial Cationic Amphiphiles 下载免费PDF全文
Yifat Berkov‐Zrihen Ido M. Herzog Raphael I. Benhamou Dr. Mark Feldman Kfir B. Steinbuch Pazit Shaul Dr. Shachar Lerer Dr. Avigdor Eldar Dr. Micha Fridman 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(11):4340-4349
Antimicrobial cationic amphiphiles derived from aminoglycoside pseudo‐oligosaccharide antibiotics interfere with the structure and function of bacterial membranes and offer a promising direction for the development of novel antibiotics. Herein, we report the design and synthesis of cationic amphiphiles derived from the pseudo‐trisaccharide aminoglycoside tobramycin and its pseudo‐disaccharide segment nebramine. Antimicrobial activity, membrane selectivity, mode of action, and structure–activity relationships were studied. Several cationic amphiphiles showed marked antimicrobial activity, and one amphiphilic nebramine derivative proved effective against all of the tested strains of bacteria; furthermore, against several of the tested strains, this compound was well over an order of magnitude more potent than the parent antibiotic tobramycin, the membrane‐targeting antimicrobial peptide mixture gramicidin D, and the cationic lipopeptide polymyxin B, which are in clinical use. 相似文献
2.
3.
4.
Henri de Maissin Philipp R. Groß Obaid Mohiuddin Dr. Moritz Weigt Luca Nagel Marvin Herzog Zirun Wang Robert Willing Dr. Wilfried Reichardt Dr. Martin Pichotka Dr. Lisa Heß Prof. Dr. Thomas Reinheckel Prof. Dr. Henning J. Jessen Prof. Dr. Robert Zeiser Prof. Dr. Michael Bock Prof. Dominik von Elverfeldt Prof. Dr. Maxim Zaitsev Dr. Sergey Korchak Dr. Stefan Glöggler Prof. Dr. Jan-Bernd Hövener Prof. Dr. Eduard Y. Chekmenev Prof. Dr. Franz Schilling Dr. Stephan Knecht Dr. Andreas B. Schmidt 《Angewandte Chemie (International ed. in English)》2023,62(36):e202306654
5.
This Note presents an experimental vibro-acoustic set-up that aims to reproduce the energy pumping phenomenon between an acoustic medium and an essentially nonlinear oscillator. It shows a one-way irreversible transfer of energy between the first acoustic mode in a tube and a thin visco-elastic membrane. To cite this article: B. Cochelin et al., C. R. Mecanique 334 (2006). 相似文献
6.
7.
8.
9.
Florian Herzog Fabio Finocchi Laetitia Soukiassian Olivier Pluchery 《Surface science》2011,605(1-2):166-173
The adsorption of 3-ethynyl-trifluoro-toluene (ETFT) on Si(100)-2 × 1 surface in ultra high vacuum is studied in the low coverage regime, through a joint experimental and theoretical approach. The STM images of both filled and empty states revealed few distinct adsorption configurations. On the basis of Density Functional Theory (DFT) calculations the STM images were simulated and three main adsorption configurations were identified, with a predominance of di-sigma bonded species that leave the benzene ring unreacted. A discussion of the reactivity of the reconstructed silicon surface towards benzene derivatives is proposed by comparing the adsorption of ETFT close related molecules, like styrene and phenylacetylene. 相似文献
10.
Equalizer technology followed by DIGE‐based proteomics for detection of cellular proteins in artificial peritoneal dialysis effluents 下载免费PDF全文
Anton Michael Lichtenauer Rebecca Herzog Silvia Tarantino Christoph Aufricht Klaus Kratochwill 《Electrophoresis》2014,35(10):1387-1394
Peritoneal dialysis effluent (PDE) represents a rich pool of potential biomarkers for monitoring disease and therapy. Until now, proteomic studies have been hindered by the plasma‐like composition of the PDE. Beads covered with a peptide library are a promising approach to remove high abundant proteins and concentrate the sample in one step. In this study, a novel approach for proteomic biomarker identification in PDEs consisting of a depletion and concentration step followed by 2D gel based protein quantification was established. To prove this experimental concept a model system of artificial PDEs was established by spiking unused peritoneal dialysis (PD) fluids with cellular proteins reflecting control conditions or cell stress. Using this procedure, we were able to reduce the amount of high abundant plasma proteins and concentrate low abundant proteins while preserving changes in abundance of proteins with cellular origin. The alterations in abundance of the investigated marker for cell stress, the heat shock proteins, showed similar abundance profiles in the artificial PDE as in pure cell culture samples. Our results demonstrate the efficacy of this system in detecting subtle changes in cellular protein expression triggered by unphysiological stress stimuli typical in PD, which could serve as biomarkers. Further studies using patients’ PDE will be necessary to prove the concept in clinical PD and to assess whether this technique is also informative regarding enriching low abundant plasma derived protein biomarker in the PDE. 相似文献