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排序方式: 共有8398条查询结果,搜索用时 15 毫秒
1.
Shuo Gu Tingting Mou Jian Chen Jing Wang Ying Zhang Meirong Cui Wenqian Hao Yue Sun Chengqin Zhang Tiantian Zhao Binbin Wei 《Journal of separation science》2022,45(10):1656-1671
Baihe-Dihuang Tang is a commonly prescribed remedy for depression. In this study, component screening with untargeted and targeted metabolomics was used to identify potential biomarkers for depression in chronic unpredictable mildly stressed rats. Using this novel identification method, the screening of organic acids, lily saponins, iridoids, and other ingredients formed the basis for subsequent metabolomics research. Baihe-Dihuang Tang supplementation in chronic unpredictable mild-stress-induced depression models, increased their body weight, sucrose preference, brain-derived neurotrophic factor deposition, and spatial exploring. Untargeted metabolomics revealed that Baihe-Dihuang Tang exerts its antidepressant effects by regulating the levels of lipids, organic acids, and its derivatives, and benzenoids in the brain, plasma, and urine of the depressed rats. Moreover, it also modulates the d -glutamine and d -glutamate metabolism and purine metabolism. Targeted metabolomics demonstrated significant reduction in l -glutamate levels in the brains of depressed rats. This could be a potential biomarker for depression. Baihe-Dihuang Tang alleviated depression by regulating the levels of l -glutamate, xanthine, and adenine in the brains of depressed rats. Together, these findings conclusively established the promising therapeutic effect of Baihe-Dihuang Tang on depression and also unraveled the underlying molecular mechanism of its potential antidepressant function. 相似文献
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Three-dimensional vertical ZnO transistors with suspended top electrodes fabricated by focused ion beam technology 下载免费PDF全文
Three-dimensional(3D)vertical architecture transistors represent an important technological pursuit,which have distinct advantages in device integration density,operation speed,and power consumption.However,the fabrication processes of such 3D devices are complex,especially in the interconnection of electrodes.In this paper,we present a novel method which combines suspended electrodes and focused ion beam(FIB)technology to greatly simplify the electrodes interconnection in 3D devices.Based on this method,we fabricate 3D vertical core-double shell structure transistors with ZnO channel and Al2O3 gate-oxide both grown by atomic layer deposition.Suspended top electrodes of vertical architecture could be directly connected to planar electrodes by FIB deposited Pt nanowires,which avoid cumbersome steps in the traditional 3D structure fabrication technology.Both single pillar and arrays devices show well behaved transfer characteristics with an Ion/Ioff current ratio greater than 106 and a low threshold voltage around 0 V.The ON-current of the 2×2 pillars vertical channel transistor was 1.2μA at the gate voltage of 3 V and drain voltage of 2 V,which can be also improved by increasing the number of pillars.Our method for fabricating vertical architecture transistors can be promising for device applications with high integration density and low power consumption. 相似文献
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First-principles study of the co-effect of carbon doping and oxygen vacancies in ZnO photocatalyst 下载免费PDF全文
Although tuning band structure of optoelectronic semiconductor-based materials by means of doping single defect is an important approach for potential photocatalysis application,C-doping or oxygen vacancy(Vo)as a single defect in ZnO still has limitations for photocatalytic activity.Meanwhile,the influence of co-existence of various defects in ZnO still lacks sufficient studies.Therefore,we investigate the photocatalytic properties of ZnOx C0.0625(x=0.9375,0.875,0.8125),confirming that the co-effect of various defects has a greater enhancement for photocatalytic activity driven by visible-light than the single defect in ZnO.To clarify the underlying mechanism of co-existence of various defects in ZnO,we perform systematically the electronic properties calculations using density functional theory.It is found that the coeffect of C-doping and Vo in ZnO can achieve a more controllable band gap than doping solely in ZnO.Moreover,the impact of the effective masses of ZnOxC0.0625(x=0.9375,0.875,0.8125)is also taken into account.In comparison with heavy Vo concentrations,the light Vo concentration(x=0.875)as the optimal component together with C-doping in ZnO,can significantly improve the visible-light absorption and benefit photocatalytic activity. 相似文献
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为了校正大扫描视场机载共形窗口引入的像差,提出一种基于固定校正板和透镜阵列的静态校正方法。首先使用固定校正板校正静态像差;然后在像面前安置固定的透镜阵列,利用透镜阵列中的各个透镜单元分别校正不同扫描角度的动态像差;最后基于所提方法设计应用在机载共形光学系统中的像差校正器。设计结果表明,所提方法在±42°的扫描视场范围内能够良好地校正共形窗口引入的像差。与其他动态或静态校正方法相比,所提方法可以实现大扫描视场机载共形光学系统像差的校正,同时降低机载共形光学系统的质量,提高系统的稳定性。 相似文献
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We show that the layered-structure BaCuS2 is a moderately correlated electron system in which the electronic structure of the CuS layer bears a resemblance to those in both cuprates and iron-based superconductors.Theoretical calculations reveal that the in-plane d-p σ*-bonding bands are isolated near the Fermi level.As the energy separation between the d and p orbitals are much smaller than those in cuprates and iron-based superconductors,BaCuS2 is expected to be moderately correlated.We suggest that this material is an ideal system to study the competitive/collaborative nature between two distinct superconducting pairing mechanisms,namely the conventional BCS electron-phonon interaction and the electron-electron correlation,which may be helpful to establish the elusive mechanism of unconventional high-temperature superconductivity. 相似文献
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Stock markets in the world are linked by complicated and dynamical relationships into a temporal network.Extensive works have provided us with rich findings from the topological properties and their evolutionary trajectories,but the underlying dynamical mechanism is still not in order.In the present work,we proposed a technical scheme to reveal the dynamical law from the temporal network.The index records for the global stock markets form a multivariate time series.One separates the series into segments and calculates the information flows between the markets,resulting in a temporal market network representing the state and its evolution.Then the technique of the Koopman decomposition operator is adopted to find the law stored in the information flows.The results show that the stock market system has a high flexibility,i.e.,it jumps easily between different states.The information flows mainly from high to low volatility stock markets.And the dynamical process of information flow is composed of many dynamic modes distribute homogenously in a wide range of periods from one month to several ten years,but there exist only nine modes dominating the macroscopic patterns. 相似文献
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为准确定量拟黑多刺蚁体内的微量元素,采用微波消解法,以HNO_(3)-H_(2)O_(2)混合酸为消解体系对样品进行前处理,选择合适的同位素,以^(103)Rh为内标测定^(52)Cr、^(55)Mn、^(60)Ni、^(63)Cu、^(66)Zn、^(75)As、^(78)Se、^(88)Sr和^(114)Cd,以^(185)Re为内标测定^(202)Hg和^(208)Pb,建立了电感耦合等离子体质谱法测定拟黑多刺蚁中11种微量元素的方法。实验发现,以HNO_(3)-H_(2)O_(2)为消解体系,样品消解完全;采用KED模式消除质谱干扰,以内标法校正基体效应;通过绘制校准曲线及测定流程空白,各元素校准曲线的相关系数均大于0.999,方法检出限为0.0005~0.011 mg/kg,方法定量限为0.0016~0.033 mg/kg。对拟黑多刺蚁实际样品进行测定,各元素的相对标准偏差(RSD,n=9)在1.2%~5.5%,加标回收率为91.2%~107%;经过实验室间比对实验,相对偏差为-3.15%~2.74%;测定六个不同产地的拟黑多刺蚁样品,结果显示不同产地样品除Cd外,其他10种微量元素的含量均存在较大差异。测定结果稳定可靠,能满足拟黑多刺蚁中11种微量金属元素含量的分析检测要求。 相似文献