烯丙基-β-环糊精基手性毛细管电色谱整体柱的一步法制备及其性能

以烯丙基-β-环糊精、甲基丙烯酸缩水甘油酯和乙二醇二甲基丙烯酸酯为功能单体,一步键合制备了环糊精聚合物毛细管整体柱.在电色谱模式下18种氨基酸对映体得到成功分离.研究发现,将修饰的环糊精衍生物作为功能单体制备出的毛细管整体柱对疏水性,含氨基和苯环的手性化合物具有良好的保留行为,并具有良好的稳定性和重现性.新型电色谱柱也被应用于手性药物的分离.     

基于冷冻熔炼的液-液萃取样品富集技术研究

本文通过对区域熔炼原理及液-液萃取技术的探讨,发展了一种简单高效的基于冷冻熔炼的液-液萃取样品富集新技术.通过理论分析,探讨了冷冻熔炼、常温液-液萃取以及冷冻熔炼液-液萃取中溶质浓度的分布特征,通过富集效率的探讨证明冷冻熔炼液-液萃取技术是液-液萃取与区域熔炼技术的结合.通过葡萄汁样品的分析,对该技术进行了评价.理论计算求得冷冻熔炼液-液萃取中相应组分的富集效率为4.5,而试验测得富集效率为4.8,两者结果一致,说明冷冻熔炼液-液萃取是一种简单高效的样品富集技术.     

Effects of charge distribution on water filling process in carbon nanotube

Using umbrella sampling technique with molecular dynamics simulation, we investigated the nanofluidic transport of water in carbon nanotube (CNT). The simulations showed that a positive charge modification to the carbon nanotube can slow down the water column growth process, while the negative charge modification to the carbon nanotube will, on the other hand, quicken the water column growth process. The free energy curves were obtained through the statistical process of water column growth under different charge distributions, and the results indicated that these free energy curves can be employed to explain the dynamical process of water column growth in the nanosized channels. Supported by the National Natural Science Foundation of China (Grant Nos. 10425420 and 20773145), the Ministry of Science and Technology of China (Grant Nos. 2006CB806200 and 2006CB932100), and the Chinese Academy of Sciences including its CNIC Supercomputer Center.