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1.
Journal of Fluorescence - Vancomycin hydrochloride (VANH) is a glycopeptide antibiotic commonly employed in the prophylaxis and therapy of various gram-positive bacterial life-threatening... 相似文献
2.
Inas A. Abdallah Sherin F. Hammad Alaa Bedair Mohamed A. Abdelaziz Neil D. Danielson Ahmed H. Elshafeey Fotouh R. Mansour 《Biomedical chromatography : BMC》2022,36(6):e5365
Favipiravir is a potential antiviral medication that has been recently licensed for Covid-19 treatment. In this work, a gadolinium-based magnetic ionic liquid was prepared and used as an extractant in dispersive liquid–liquid microextraction (DLLME) of favipiravir in human plasma. The high enriching ability of DLLME allowed the determination of favipiravir in real samples using HPLC/UV with sufficient sensitivity. The effects of several variables on extraction efficiency were investigated, including type of extractant, amount of extractant, type of disperser and disperser volume. The maximum enrichment was attained using 50 mg of the Gd-magnetic ionic liquid (MIL) and 150 μl of tetrahydrofuran. The Gd-based MIL could form a supramolecular assembly in the presence of tetrahydrofuran, which enhanced the extraction efficiency of favipiravir. The developed method was validated according to US Food and Drug Administration bioanalytical method validation guidelines. The coefficient of determination was 0.9999, for a linear concentration range of 25 to 1.0 × 105 ng/ml. The percentage recovery (accuracy) varied from 99.83 to 104.2%, with RSD values (precision) ranging from 4.07 to 11.84%. The total extraction time was about 12 min and the HPLC analysis time was 5 min. The method was simple, selective and sensitive for the determination of favipiravir in real human plasma. 相似文献
3.
Sateesh K. A. Yaliwal V. S. Soudagar Manzoore Elahi M. Banapurmath N. R. Fayaz H. Safaei Mohammad Reza Elfasakhany Ashraf EL-Seesy Ahmed I. 《Journal of Thermal Analysis and Calorimetry》2022,147(10):5897-5911
Journal of Thermal Analysis and Calorimetry - Various nanofluids (NFs) have been prepared using nanoparticles (NPs) for dual fuel engine application in this present work. In the initial segment of... 相似文献
4.
Ahmed F. Khanam Achiya Samylingam L. Aslfattahi Navid Saidur R. 《Journal of Thermal Analysis and Calorimetry》2022,147(22):12669-12692
Journal of Thermal Analysis and Calorimetry - The present study numerically investigates the optimization of thermal performance in a dimpled channel using a promising genre of nanofluid which is... 相似文献
5.
Ezzat Hany G. Bayoumi Ashraf H. Sherbiny Farag F. El-Morsy Ahmed M. Ghiaty Adel Alswah Mohamed Abulkhair Hamada S. 《Molecular diversity》2021,25(1):291-306
Molecular Diversity - Many shreds of evidence have recently correlated A2B receptor antagonism with anticancer activity. Hence, the search for an efficient A2B antagonist may help in the... 相似文献
6.
7.
Syed Mohammed Basheeruddin Asdaq Earla Swathi Sunil S Dhamanigi Mohammed Asad Yahya Ali Mohzari Ahmed A. Alrashed Abdulrahman S. Alotaibi Batool Mohammed Alhassan Sreeharsha Nagaraja 《Molecules (Basel, Switzerland)》2020,25(22)
The carrot plant (Daucus carota) and its components are traditionally reported for the management of gastric ulcers. This study was performed to evaluate the role of carrot when administered concurrently with a conventional antiulcer treatment, pantoprazole, in alleviating gastric and duodenal ulcers in female experimental animals. The study involved standard animal models to determine the ulcer preventive effect using pylorus ligation, ethanol, and stress induced acute gastric ulcer models and duodenal ulcer models involving cysteamine. Acetic acid-induced chronic gastric ulcer and indomethacin-induced gastric ulcer models were used to evaluate the ulcer healing effect. Carrot fruit (500 mg/kg) and its co-administration with pantoprazole produced significant protection in an ethanol- and stress-induced acute gastric ulcer and cysteamine-induced duodenal ulcer. The healing of the acetic acid-induced chronic gastric ulcer was also augmented with this combination. Both total proteins and mucin contents were significantly increased in indomethacin-induced gastric ulcers. Similarly, in pylorus ligation, the pepsin content of gastric juice, total acidity, and free acidity were reduced. Overall, both ulcer preventive effects and ulcer healing properties of the pantoprazole were significantly enhanced in animals who received the co-administration of carrot fruit (500 mg/kg). 相似文献
8.
Ahmed M. Abdel-Megied Wagdy M. Eldehna Mohamed A. Abdelrahman Fawzy A. Elbarbry 《Molecules (Basel, Switzerland)》2020,25(23)
In the present study, a sensitive and fully validated bioanalytical high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for the quantitative determination of three newly synthesized carbonic anhydrases inhibitors (CAIs) with potential antitumor activity in human plasma. The analytes and the internal standard (IS) were extracted using 1.5 mL acetonitrile from only 450 µL aliquots of human plasma to achieve the desired protein precipitation. Chromatographic separations were achieved on Phenomenex Kinetex® C18 column (100 × 4.6 mm, 2.6 µm) using a binary gradient elution mode with a run time of less than 6 min. The mobile phase consisted of solvent (A): 0.1% formic acid in 50% methanol and solvent B: 0.1% formic acid in acetonitrile (30:70, v/v), pumped at a flow rate of 0.8 mL/min. Detection was employed using triple quadrupole tandem mass spectrometer (API 3500) equipped with an electrospray ionization (ESI) source in the positive ion mode. Multiple reaction monitoring (MRM) mode was selected for quantitation through monitoring the precursor-to-parent ion transition at m/z 291.9 → 173.0, m/z 396.9 → 225.1, m/z 388.9 → 217.0, and m/z 146.9 → 91.0 for AW-9a, WES-1, WES-2, and Coumarin (IS), respectively. Linearity was computed using the weighted least-squares linear regression method (1/x2) over a concentration range of 1–1000, 2.5–800, and 5–500 ng/mL for AW-9a, WES-1, and WES-2; respectively. The bioanalytical LC-MS/MS method was fully validated as per U.S. Food and Drug Administration (FDA) guidelines with all respect to linearity, accuracy, precision, carry-over, selectivity, dilution integrity, and stability. The proposed LC-MS/MS method was applied successfully for the determination of all investigated drugs in spiked human plasma with no significant matrix effect, which is a crucial cornerstone in further therapeutic drug monitoring of newly developed therapeutic agents. 相似文献
9.
Nassr Abu Bakr Ahmed Amine Kottakkat Tintula Bron Michael 《Journal of Solid State Electrochemistry》2020,24(1):131-136
Journal of Solid State Electrochemistry - Cobalt oxide nanoparticles supported on multiwalled carbon nanotubes (CoOx/CNTs) were prepared by a facile and rapid solid-state synthesis using microwave... 相似文献
10.
Abou-Dina M. S. Helal M. A. Ghaleb Ahmed F. Kaoullas George Georgiou Georgios C. 《Meccanica》2020,55(7):1499-1507
Meccanica - The occurrence of slip complicates the estimation of the viscosity in rheometric flows. Thus, special analyses and experimental protocols are needed in order to obtain reliable... 相似文献