A luminescent Zn(II)-Containing Complex: Selective Sensing of Cr(VI) Anion and Application Values on Tuberculosis Care Through Increasing the Antibacterial Response of Macrophages

Journal of Fluorescence - A new Zn(II)-bearing metal-organic framework (MOF), namely, {[Zn2(L)2(H2O)]·8H2O·DMF}n (1) has been generated via applying...     

Maltol as a Novel Agent Protecting SH-SY5Y Cells Against Hemin-induced Ferroptosis

Ferroptosis triggered by hemin is regarded as a primary factor accounting for neuronal death secondary to intracerebral hemorrhage. Thus, compounds with inhibitory effect on hemin-induced ferroptosis might be potential medicines to prevent neuronal death caused by intracerebral hemorrhage. Herein, we investigate whether maltol could alleviate hemin-induced SH-SY5Y cell ferroptosis and its potential mechanisms. It is found that maltol effectively prevents hemin-induced SH-SY5Y cell ferroptosis via three pathways. The first one is inhibiting intracellular iron increase via preventing upregulation of transferrin receptor, the second one is alleviating lipid peroxidation via attenuating H₂O₂ generation by NOX4 and promoting H₂O₂ clearance by catalase, and the third one is to reduce peroxidized lipids via maintaining GPX4/GSH pathway. Therefore, maltol is a novel agent preventing hemin-induced SH-SY5Y cell ferroptosis.     

A perimeter-based angle measure in Minkowski planes

Measuring angles in the Euclidean plane is a well-known topic, but for general normed planes there exists a variety of different concepts. These can be of a special kind, e.g. also preserving special orthogonality types. But these concepts are no angle measures in the sense of measure theory since they are not additive. This motivates us to define a new angle measure for normed planes that is in fact a measure in the sense of measure theory. Furthermore, we look at related types of rotation and reflection.     

Isolated resonances and nonlinear damping

We analyze isolated resonance curves (IRCs) in single-degree-of-freedom systems possessing nonlinear damping. Through the combination of singularity theory and the averaging method, the onset and merging of IRCs, which coincide to isola and simple bifurcation singularities, respectively, can be analytically predicted. Numerical simulations confirm the accuracy of the analytical developments. Another important finding of this paper is that we unveil a geometrical connection between the topology of the damping force and IRCs. Specifically, we demonstrate that extremas and zeros of the damping force correspond to the appearance and merging of IRCs. Considering a damping force possessing several minima and maxima confirms the general validity of the analytical result. It also evidences a very complex scenario for which different IRCs are created, co-exist and then merge together to form a super IRC which eventually merges with the main resonance peak.     

Parametrix for the localization of the Bergman metric on strictly pseudoconvex domains

We give the parameter version of a localization theorem for the Bergman metric near the boundary points of strictly pseudoconvex domains. The approximation theorem for square integrable holomorphic functions on such domains in the spirit of Graham-Kerzman is proved in the hereby paper, as well.     

An enriched damage-frictional cohesive-zone model incorporating stress multi-axiality

The paper presents an interphase cohesive zone model (CZM) incorporating stress multi-axiality devised to capture, by simplified micro-modeling, the influence of the in-plane strain and stress state in the mechanical response of the CZM. Moreover, the model is able to account for the Poisson-related effect in the interphase, which can play an important role in the modeling of heterogeneous masonry elements. From the constitutive point of view, the proposed formulation couples damage and friction by addressing a smooth transition from a quasi-brittle response to a residual frictional behavior described by a Coulomb law with unilateral contact. As in-plane stresses are accounted for, damage activation and evolution are governed by a Drucker–Prager law with linear softening. A predictor-corrector procedure based on a backward Euler scheme is detailed for integrating the nonlinear evolutive problem together with the related tangent operator which consistently linearizes the algorithmic strategy. This framework is embedded into a kinematically-enriched finite element interphase formulation incorporating stress multi-axiality. The modeling features of the resulting numerical tool are tested both at the local level, for the typical interphase point, and in meso-structural tests consisting of brick-mortar triplets, investigating the capability of the proposed model and numerical procedure to simulate the brick-mortar decohesion mechanism during confined slip tests.     

Static Charge Susceptibility in the <Emphasis Type="Italic">t-J-V</Emphasis> Model

We describe the static charge susceptibility and correlation function of the charge density in the twodimensional t-J-V model based on the method of equations of motion for the relaxation functions of the Hubbard operators. We obtain the dependence of the susceptibility and correlation function on the hole concentration and temperature. Charge density waves can develop if the intersite Coulomb interaction is sufficiently strong.     

Electroosmosis modulated peristaltic biorheological flow through an asymmetric microchannel: mathematical model

A theoretical study is presented of peristaltic hydrodynamics of an aqueous electrolytic non-Newtonian Jeffrey bio-rheological fluid through an asymmetric microchannel under an applied axial electric field. An analytical approach is adopted to obtain the closed form solution for velocity, volumetric flow, pressure difference and stream function. The analysis is also restricted under the low Reynolds number assumption (Stokes flow) and lubrication theory approximations (large wavelength). Small ionic Peclét number and Debye–Hückel linearization (i.e. wall zeta potential ≤ 25 mV) are also considered to simplify the Nernst–Planck and Poisson–Boltzmann equations. Streamline plots are also presented for the different electro-osmotic parameter, varying magnitudes of the electric field (both aiding and opposing cases) and for different values of the ratio of relaxation to retardation time parameter. Comparisons are also included between the Newtonian and general non-Newtonian Jeffrey fluid cases. The results presented here may be of fundamental interest towards designing lab-on-a-chip devices for flow mixing, cell manipulation, micro-scale pumps etc. Trapping is shown to be more sensitive to an electric field (aiding, opposing and neutral) rather than the electro-osmotic parameter and viscoelastic relaxation to retardation ratio parameter. The results may also help towards the design of organ-on-a-chip like devices for better drug design.     

A Framework for Characterizing Structural Uncertainty in Large-Eddy Simulation Closures

Motivated by the sizable increase of available computing resources, large-eddy simulation of complex turbulent flow is becoming increasingly popular. The underlying filtering operation of this approach enables to represent only large-scale motions. However, the small-scale fluctuations and their effects on the resolved flow field require additional modeling. As a consequence, the assumptions made in the closure formulations become potential sources of incertitude that can impact the quantities of interest. The objective of this work is to introduce a framework for the systematic estimation of structural uncertainty in large-eddy simulation closures. In particular, the methodology proposed is independent of the initial model form, computationally efficient, and suitable to general flow solvers. The approach is based on introducing controlled perturbations to the turbulent stress tensor in terms of magnitude, shape and orientation, such that propagation of their effects can be assessed. The framework is rigorously described, and physically plausible bounds for the perturbations are proposed. As a means to test its performance, a comprehensive set of numerical experiments are reported for which physical interpretation of the deviations in the quantities of interest are discussed.