全文获取类型
收费全文 | 492篇 |
免费 | 18篇 |
国内免费 | 11篇 |
专业分类
化学 | 332篇 |
晶体学 | 7篇 |
力学 | 28篇 |
综合类 | 1篇 |
数学 | 63篇 |
物理学 | 90篇 |
出版年
2023年 | 19篇 |
2022年 | 19篇 |
2021年 | 23篇 |
2020年 | 23篇 |
2019年 | 28篇 |
2018年 | 18篇 |
2017年 | 21篇 |
2016年 | 24篇 |
2015年 | 20篇 |
2014年 | 22篇 |
2013年 | 49篇 |
2012年 | 38篇 |
2011年 | 40篇 |
2010年 | 30篇 |
2009年 | 24篇 |
2008年 | 34篇 |
2007年 | 13篇 |
2006年 | 13篇 |
2005年 | 12篇 |
2004年 | 8篇 |
2003年 | 7篇 |
2002年 | 7篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1966年 | 1篇 |
1935年 | 1篇 |
排序方式: 共有521条查询结果,搜索用时 31 毫秒
1.
2.
SHANG Anqi ZHAO Lele LI Zhenhua CHENG Zhuang JIN Haixu FENG Zijun CHEN Zhijun ZHANG Haiquan LU Ping 《高等学校化学研究》2022,38(6):1461-1466
Near-infrared(NIR) fluorescent materials with high photoluminescent quantum yields(PLQYs) have wide application prospects. Therefore, we design and synthesize a D-A type NIR organic molecule, TPATHCNE, in which triphenylamine and thiophene are utilized as the donors and fumaronitrile is applied as the acceptor. We systematically investigate its molecular structure and photophysical property. TPATHCNE shows high Tgof 110℃ and Td of 385℃ and displays an aggregation-induced emission(AIE) property. A narrow optical bandgap of 1.65 eV is obtained. The non-doped film of TPATHCNE exhibits a high PLQY of 40.3% with an emission peak at 732 nm, which is among the best values of NIR emitters. When TPATHCNE is applied in organic light-emitting diode(OLED), the electroluminescent peak is located at 716 nm with a maximum external quantum efficiency of 0.83%. With the potential in cell imaging, the polystyrene maleic anhydride(PMSA) modified TPATHCNE nanoparticles(NPs) emit strong fluorescence when labeling HeLa cancer cells, suggesting that TPATHCNE can be used as a fluorescent carrier for specific staining or drug delivery for cellular imaging. TPATHCNE NPs fabricated by bovine serum protein(BSA) are cultivated with mononuclear yeast cells, and the intense intracellular red fluorescence indicates that it can be adopted as a specific stain for imaging. 相似文献
3.
Wenxiang Liu Lele Lu Qiang Li Boyuan Wu Ruizhe Zhang Wei Shi Peng Cheng 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(53):12206-12211
Photocatalytic hydrogen evolution by water splitting is highly important for the application of hydrogen energy and the replacement of fossil fuel by solar energy, which needs the development of efficient catalysts with long-term catalytic stability under light irradiation in aqueous solution. Herein, Zn0.5Cd0.5S solid solution was synthesized by a metal–organic framework-templated strategy and then loaded with MoS2 by a hydrothermal method to fabricate a MoS2/Zn0.5Cd0.5S heterojunction for photocatalytic hydrogen evolution. The composition of MoS2/Zn0.5Cd0.5S was fine-tuned to obtain the optimized 5 wt % MoS2/Zn0.5Cd0.5S heterojunction, which showed a superior hydrogen evolution rate of 23.80 mmol h−1 g−1 and steady photocatalytic stability over 25 h. The photocatalytic performance is due to the appropriate composition and the formation of an intimate interface between MoS2 and Zn0.5Cd0.5S, which endows the photocatalyst with high light-harvesting ability and effective separation of photogenerated carriers. 相似文献
4.
Doiphode Vidya Vairale Priti Sharma Vidhika Waghmare Ashish Punde Ashvini Shinde Pratibha Shah Shruti Pandharkar Subhash Hase Yogesh Aher Rahul Nair Shruthi Jadkar Vijaya Bade Bharat Prasad Mohit Rondiya Sachin Jadkar Sandesh 《Journal of Solid State Electrochemistry》2021,25(6):1835-1846
Journal of Solid State Electrochemistry - Herein, we report the synthesis of ZnO nanorod films onto FTO (fluorine-doped tin oxide) substrates using the solution-processed electrodeposition method.... 相似文献
5.
6.
Dr. Fengyun Shen Zijian Xiong Dr. Yumin Wu Prof. Dr. Rui Peng Yue Wang Dr. Lele Sun Prof. Dr. Chunhai Fan Prof. Dr. Zhuang Liu 《Angewandte Chemie (International ed. in English)》2023,62(21):e202301147
Peptide vaccines have advantages in easy fabrication and high safety, but their effectiveness is hampered by the poor immunogenicity of the epitopes themselves. Herein, we constructed a series of framework nucleic acids (FNAs) with regulated rigidity and size to precisely organize epitopes in order to reveal the influence of epitope spacing and carrier rigidity on the efficiency of peptide vaccines. We found that assembling epitopes on rigid tetrahedral FNAs (tFNAs) with the appropriate size could efficiently enhance their immunogenicity. Further, by integrating epitopes from SARS-CoV-2 on preferred tFNAs, we constructed a COVID-19 peptide vaccine which could induce high titers of IgG against the receptor binding domain (RBD) of SARS-CoV-2 spike protein and increase the ratio of memory B and T cells in mice. Considering the good biocompatibility of tFNAs, our research provides a new idea for developing efficient peptide vaccines against viruses and possibly other diseases. 相似文献
7.
Dr. Haiyuan Zou Gang Zhao Hao Dai Dr. Hongliang Dong Wen Luo Prof. Lei Wang Prof. Zhouguang Lu Prof. Yi Luo Dr. Guozhen Zhang Prof. Lele Duan 《Angewandte Chemie (International ed. in English)》2023,62(6):e202217220
Fine-tuning electronic structures of single-atom catalysts (SACs) plays a crucial role in harnessing their catalytic activities, yet challenges remain at a molecular scale in a controlled fashion. By tailoring the structure of graphdiyne (GDY) with electron-withdrawing/-donating groups, we show herein the electronic perturbation of Cu single-atom CO2 reduction catalysts in a molecular way. The elaborately introduced functional groups (−F, −H and −OMe) can regulate the valance state of Cuδ+, which is found to be directly scaled with the selectivity of the electrochemical CO2-to-CH4 conversion. An optimum CH4 Faradaic efficiency of 72.3 % was achieved over the Cu SAC on the F-substituted GDY. In situ spectroscopic studies and theoretical calculations revealed that the positive Cuδ+ centers adjusted by the electron-withdrawing group decrease the pKa of adsorbed H2O, promoting the hydrogenation of intermediates toward the CH4 production. Our strategy paves the way for precise electronic perturbation of SACs toward efficient electrocatalysis. 相似文献
8.
Shuai Zhao Prof. Shaohua Zhang Huijun Hu Yangchang Cheng Kexuan Zou Prof. Jie Song Dr. Jinqi Deng Prof. Lele Li Prof. Xiao-Bing Zhang Prof. Guoliang Ke Prof. Jiashu Sun 《Angewandte Chemie (International ed. in English)》2023,62(24):e202303121
Mature microRNAs (miRNAs) in extracellular vesicles (EVs) are involved in different stages of cancer progression, yet it remains challenging to precisely detect mature miRNAs in EVs due to the presence of interfering RNAs (such as longer precursor miRNAs, pre-miRNAs) and the low abundance of tumor-associated miRNAs. By leveraging the size-selective ability of DNA cages and polyethylene glycol (PEG)-enhanced thermophoretic accumulation of EVs, we devised a DNA cage-based thermophoretic assay for highly sensitive, selective, and in situ detection of mature miRNAs in EVs with a low limit of detection (LoD) of 2.05 fM. Our assay can profile EV mature miRNAs directly in serum samples without the interference of pre-miRNAs and the need for ultracentrifugation. A clinical study showed that EV miR-21 or miR-155 had an overall accuracy of 90 % for discrimination between breast cancer patients and healthy donors, which outperformed conventional molecular probes detecting both mature miRNAs and pre-miRNAs. We envision that our assay can advance EV miRNA-based diagnosis of cancer. 相似文献
9.
Ashish J. Radia Jaydeep N. Lalpara Ishita J. Modasiya Gaurang G. Dubal 《Journal of heterocyclic chemistry》2021,58(2):612-621
A modest, efficient, and mild synthetic procedure has been developed for the synthesis of novel series of 1,3,4-oxadiazole containing azaspirocycles derivatives. The reaction of 1,3,4-oxadiazole derivative with diverse azaspiro compounds under room temperature condition with helps of sodium iodide catalyst and polar aprotic solvent. Numerous compensations of this strategy embrace less time required, yield increment, consumption of all reactants, and mild condition. All synthesized compounds evaluated for in vitro antidiabetic and antibacterial screening. Among them some compounds show significant biological response. 相似文献
10.
生物分子与纳米材料作用形成的“蛋白冠”影响纳米材料的物理和化学性质, 目前缺少有效的原位实时技术监测蛋白冠的形成过程. 本研究基于二氧化硅胶体晶体薄膜和反射干涉光谱法, 研究了三种代表性血液蛋白质在二氧化硅纳米粒子表面的蛋白冠形成过程, 结果表明这三种蛋白具有不同的蛋白冠形成过程及参数; 研究了人血清白蛋白在三种表面曲率的二氧化硅表面的蛋白冠形成过程, 结果表明曲率越大时, 蛋白冠形成速率越快, 厚度越大. 以血浆和全血样品为生物环境开展蛋白冠形成过程研究, 结果表明本研究的监测方法可以直接用于血浆和全血在纳米粒子表面蛋白冠的形成过程监测, 为纳米材料与生物分子的相互作用研究提供了一种简单可靠的评价技术. 相似文献