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排序方式: 共有94条查询结果,搜索用时 15 毫秒
1.
Synthesis and Evaluation of GdIII‐Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate‐Specific Membrane Antigen 下载免费PDF全文
Dr. Sangeeta Ray Banerjee Dr. Ethel J. Ngen Matthew W. Rotz Dr. Samata Kakkad Ala Lisok Richard Pracitto Mrudula Pullambhatla Dr. Zhengping Chen Dr. Tariq Shah Dr. Dmitri Artemov Dr. Thomas J. Meade Dr. Zaver M. Bhujwalla Dr. Martin G. Pomper 《Angewandte Chemie (International ed. in English)》2015,54(37):10778-10782
Magnetic resonance (MR) imaging is advantageous because it concurrently provides anatomic, functional, and molecular information. MR molecular imaging can combine the high spatial resolution of this established clinical modality with molecular profiling in vivo. However, as a result of the intrinsically low sensitivity of MR imaging, high local concentrations of biological targets are required to generate discernable MR contrast. We hypothesize that the prostate‐specific membrane antigen (PSMA), an attractive target for imaging and therapy of prostate cancer, could serve as a suitable biomarker for MR‐based molecular imaging. We have synthesized three new high‐affinity, low‐molecular‐weight GdIII‐based PSMA‐targeted contrast agents containing one to three GdIII chelates per molecule. We evaluated the relaxometric properties of these agents in solution, in prostate cancer cells, and in an in vivo experimental model to demonstrate the feasibility of PSMA‐based MR molecular imaging. 相似文献
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Salahudeen Nurudeen Ahmed Abdulkarim S. Al-Muhtaseb Ala’a H. Dauda Mohammed Jibril Baba Y. Viswanadham Nagabhatla Saxena Sandeep K. 《Research on Chemical Intermediates》2017,43(1):467-479
Research on Chemical Intermediates - This study presents the synthesis of rare earth-doped Y (RE Y) zeolite, its application in formulation of a fluid catalytic cracking (FCC) catalyst and the... 相似文献
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Four C-2 unsubstituted naphtho[2,3-b]furan-4,9-quinones were prepared via the corresponding phthalides obtained by directed ortho-metalation-based route. 相似文献
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Peng He Xiaolin Hou Ala Aldahan Göran Possnert 《Journal of Radioanalytical and Nuclear Chemistry》2014,299(1):249-253
Relatively large amounts of radioactive iodine 129I (T 1/2 = 15.7 Ma) have been documented in seawater such as the English Channel, the Irish Sea and the North Sea. Data on the concentration of the iodine isotopes in waters of the Celtic Sea are missing. Aiming to provide first 129I data in the Celtic Sea and compare them with levels in the other close-by seawater bodies, surface seawater samples were analyzed for the determination of 127I and 129I concentrations. The results revealed a high level of 129I in these waters and suggest strong influence by liquid discharges from La Hague and Sellafield reprocessing facilities. 127I concentrations are rather constant while the 129I/127I ratio reaches up to 2.8 × 10?8 (ranging from 10?10 to 10?8), which is 2–4 orders of magnitude higher than pre-nuclear era natural level. Transport of 129I to the Celtic Sea is difficult to depict accurately since available data are sparse. Most likely, however, that discharges originated from La Hague may have more influence on the Celtic Sea 129I concentrations than the Sellafield. Comprehensive surface water and depth profiles 129I data will be needed in the future for assessment of environmental impact in the region. 相似文献
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Eun Joung Choi Eunha Kim Youngjun Lee Ala Jo Seung Bum Park 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2014,126(5):1370-1374
Fluorescence imaging enables the uniquely sensitive observation of functional‐ and molecular‐recognition events in living cells. However, only a limited range of biological processes have been subjected to imaging because of the lack of a design strategy and difficulties in the synthesis of biosensors. Herein, we report a facile synthesis of emission‐tunable and predictable Seoul‐Fluors, 9‐aryl‐1,2‐dihydrolopyrrolo[3,4‐b]indolizin‐3‐ones, with various R1 and R2 substituents by coinage‐metal‐catalyzed intramolecular 1,3‐dipolar cycloaddition and subsequent palladium‐mediated C H activation. We also showed that the quantum yields of Seoul‐Fluors are controlled by the electronic nature of the substituents, which influences the extent of photoinduced electron transfer. On the basis of this understanding, we demonstrated our design strategy by the development of a Seoul‐Fluor‐based chemosensor 20 for reactive oxygen species that was not accessible by a previous synthetic route. 相似文献
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Ala Hasan 《Heat and Mass Transfer》2005,41(8):724-733
The thermal-hydraulic performance of five oval tubes is experimentally investigated and compared with that for a circular tube in a cross-flow of air. The range of Reynolds numbers ReD is approximately between 1,000 and 11,000. The nominal axis ratios R (major axis/minor axis) for three of the investigated oval tubes are 2, 3, and 4. Two other configurations of oval tubes are also tested, an oval tube R=3 with two wires soldered on its upper and lower top positions, and a cut-oval tube. The performance of the tubes is corrected for the effects of area blockage and turbulence intensity. The measurement results show that the mean Nusselt numbers NuD for the oval tubes are close to that for the circular tube for ReD<4,000. For a higher ReD, the NuD for the oval tubes is lower than that for the circular tube and it decreases with the increase in the axis ratio R. The drag coefficients Cd for the tubes are measured and the combined thermal-hydraulic performance is indicated by the ratio NuD/Cd, which shows a better combined performance for the oval tubes. 相似文献
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The new compounds podophyllotoxone oxime (3) and epipodophyllotoxin azide (5) were prepared. The known dehydroanhydropicropodophyllin (6) was unexpectedly obtained from podophyllotoxin (1) by treatment with TMSCl/NaI/MeCN. 相似文献