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Bruchiel-Spanier Netta Betsis Shelly Naim Guy Mandler Daniel 《Journal of Solid State Electrochemistry》2022,26(9):1871-1896
Journal of Solid State Electrochemistry - The demand for medical implants has rapidly increased over the last decades. These artificial devices should possess various properties such as... 相似文献
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Segev R Benveniste M Hulata E Cohen N Palevski A Kapon E Shapira Y Ben-Jacob E 《Physical review letters》2002,88(11):118102
We measured the long term spontaneous electrical activity of neuronal networks with different sizes, grown on lithographically prepared substrates and recorded with multi-electrode-array technology. The time sequences of synchronized bursting events were used to characterize network dynamics. All networks exhibit scale-invariant Lévy distributions and long-range correlations. These observations suggest that different-size networks self-organize to adjust their activities over many time scales. As predictions of current models differ from our observations, this calls for revised models. 相似文献
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Federico Comitani Netta Cohen Jamie Ashby Dominic Botten Sarah C. R. Lummis Carla Molteni 《Journal of computer-aided molecular design》2014,28(1):35-48
The resistance to dieldrin (RDL) receptor is an insect pentameric ligand-gated ion channel (pLGIC). It is activated by the neurotransmitter γ-aminobutyric acid (GABA) binding to its extracellular domain; hence elucidating the atomistic details of this interaction is important for understanding how the RDL receptor functions. As no high resolution structures are currently available, we built homology models of the extracellular domain of the RDL receptor using different templates, including the widely used acetylcholine binding protein and two pLGICs, the Erwinia Chrysanthemi ligand-gated ion channel (ELIC) and the more recently resolved GluCl. We then docked GABA into the selected three dimensional structures, which we used as starting points for classical molecular dynamics simulations. This allowed us to analyze in detail the behavior of GABA in the binding sites, including the hydrogen bond and cation-π interaction networks it formed, the conformers it visited and the possible role of water molecules in mediating the interactions; we also estimated the binding free energies. The models were all stable and showed common features, including interactions consistent with experimental data and similar to other pLGICs; differences could be attributed to the quality of the models, which increases with increasing sequence identity, and the use of a pLGIC template. We supplemented the molecular dynamics information with metadynamics, a rare event method, by exploring the free energy landscape of GABA binding to the RDL receptor. Overall, we show that the GluCl template provided the best models. GABA forming direct salt-bridges with Arg211 and Glu204, and cation-π interactions with an aromatic cage including Tyr109, Phe206 and Tyr254, represents a favorable binding arrangement, and the interaction with Glu204 can also be mediated by a water molecule. 相似文献
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Alexander G. Shtukenberg Ran Drori Elena V. Sturm Netta Vidavsky Asaf Haddad Jason Zheng Lara A. Estroff Haim Weissman Sharon G. Wolf Eyal Shimoni Chao Li Noalle Fellah Efi Efrati Bart Kahr 《Angewandte Chemie (International ed. in English)》2020,59(34):14593-14601
The growth of spontaneously twisted crystals is a common but poorly understood phenomenon. An analysis of the formation of twisted crystals of a metastable benzamide polymorph (form II ) crystallizing from highly supersaturated aqueous and ethanol solutions is given here. Benzamide, the first polymorphic molecular crystal reported (1832), would have been the first helicoidal crystal observed had the original authors undertaken an analysis by light microscopy. Polymorphism and twisting frequently concur as they are both associated with high thermodynamic driving forces for crystallization. Optical and electron microscopies as well as electron and powder X‐ray diffraction reveal a complex lamellar structure of benzamide form II needle‐like crystals. The internal stress produced by the overgrowth of lamellae is shown to be able to create a twist moment that is responsible for the observed non‐classical morphologies. 相似文献
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Dr. Alexander G. Shtukenberg Prof. Ran Drori Dr. Elena V. Sturm Dr. Netta Vidavsky Asaf Haddad Jason Zheng Prof. Lara A. Estroff Dr. Haim Weissman Dr. Sharon G. Wolf Dr. Eyal Shimoni Chao Li Noalle Fellah Prof. Efi Efrati Prof. Bart Kahr 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(34):14701-14709
The growth of spontaneously twisted crystals is a common but poorly understood phenomenon. An analysis of the formation of twisted crystals of a metastable benzamide polymorph (form II ) crystallizing from highly supersaturated aqueous and ethanol solutions is given here. Benzamide, the first polymorphic molecular crystal reported (1832), would have been the first helicoidal crystal observed had the original authors undertaken an analysis by light microscopy. Polymorphism and twisting frequently concur as they are both associated with high thermodynamic driving forces for crystallization. Optical and electron microscopies as well as electron and powder X-ray diffraction reveal a complex lamellar structure of benzamide form II needle-like crystals. The internal stress produced by the overgrowth of lamellae is shown to be able to create a twist moment that is responsible for the observed non-classical morphologies. 相似文献
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Hendler N Fadeev L Mentovich ED Belgorodsky B Gozin M Richter S 《Chemical communications (Cambridge, England)》2011,47(26):7419-7421
A method of synthesizing stable chiral Ag nanoparticles inside a natural mucin glycoprotein is demonstrated. The reaction is carried out without the help of an external reducing agent, by utilizing the reducing properties of the host mucin. A chiral spectrum is detected in the visible range, indicating the formation of a new type of chiral Ag nanoparticles-containing biomaterial. 相似文献
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