排序方式: 共有15条查询结果,搜索用时 31 毫秒
1.
Sakram B. Madhu P. Sonyanaik B. Rambabu S. Ravi D. Kurumanna A. 《Russian Journal of General Chemistry》2018,88(6):1224-1227
Russian Journal of General Chemistry - A new methodology has been developed for the synthesis of novel 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylates from 2-aminonicotinaldehyde,... 相似文献
2.
Sakram B. Ashok K. Rambabu S. Sonyanaik B. Ravi D. 《Russian Journal of General Chemistry》2017,87(8):1794-1799
Russian Journal of General Chemistry - Synthesis of substituted 1,8-naphthyridines based on 2-aminonicotinaldehyde under mild conditions is studied. Out of three electrophilic iodine sources (I2,... 相似文献
3.
B. Sakram B. Sonyanaik K. Ashok S. Rambabu S. K. Johnmiya 《Research on Chemical Intermediates》2016,42(3):1699-1705
4.
Sonyanaik B. Sakram B. Shyam P. Madhu P. Govan M. 《Russian Journal of General Chemistry》2018,88(7):1495-1501
Russian Journal of General Chemistry - An efficient synthesis of 6-(2-chloro-4-fluorophenyl)-9-phenylimidazo[1,2-a][1,8]naphthyridine derivatives by the reaction of phenacyl bromide with... 相似文献
5.
Moorthiamma Sarathy Ganesan Kamatchi Kanmani Raja Sankaranarayanan Murugesan Banoth Karankumar Faheem Faheem Sappanimuthu Thirunavukkarasu Gauri Shetye Rui Ma Scott G. Franzblau Baojie Wan Gurusamy Rajagopal 《Journal of heterocyclic chemistry》2021,58(4):952-968
A series of novel quinoline-proline hybrids ( 11a-g ) and quinoline-proline-1,2,3-triazole hybrids ( 12-14 ) were synthesized by click chemistry based on molecular hybridization concept and were characterized by NMR, mass spectrometry, and elemental analysis. All the titled target compounds were tested for antitubercular activity by MABA and LORA methods by in vitro. Interestingly, two compounds (2R,4S)-1-((2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl)-methyl)-4-(4-nitrobenzamido)-N-phenylpyrrolidine-2-carboxamide ( 11b ) and (2R,4S)-1-((2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl)-methyl)-4-(4-fluorobenzamido)-N-phenylpyrrolidine-2-carboxamide ( 11c ) exhibited significant activity against the tested Mycobacterium tuberculosis H37Rv strain. Further, the cytotoxicity ( CC 50 ) profile of the titled compounds against the Vero cell was performed and discussed. A molecular docking study of the hit compounds ( 11b and 11c ) was also performed to find their putative binding interaction with the active site of the target proteins. Finally, in silico ADMET properties were also predicted for all the synthesized molecules to evaluate their drug-likeness behavior. 相似文献
6.
Kurumanna A. Ashok K. Rambabu S. Sonyanaik B. Ravi D. Madhu P. Sakram B. 《Russian Journal of General Chemistry》2017,87(11):2703-2711
Russian Journal of General Chemistry - A novel and efficient aromatization of tetrahydro-β-carbolines under mild conditions using K2S2O8 as a catalyst was developed. The method is applicable... 相似文献
7.
Sakkani Nagaraju Kota Sathish Neeli Satyanarayana Banoth Paplal Dhurke Kashinath 《Journal of heterocyclic chemistry》2020,57(1):469-476
Catalyst-free synthesis of the isoxazole-spirooxindole-tetrahydrothiophene hybrids is reported. Formation of 1,4-thia-Michael and intramolecular aldol reactions were observed (instead of 1,6-thia-Michael followed by vinylogous Henry reactions) in a regioselective fashion to give new isoxazole-spirooxindole-tetrahydrothiophene hybrids with excellent yields. 相似文献
8.
9.
Sakram B. Rambabu S. Ashok K. Sonyanaik B. Ravi D. 《Russian Journal of General Chemistry》2016,86(12):2737-2743
Russian Journal of General Chemistry - A simple and high yielding method for synthesized benzothiazoles and benzimidazole in water under micro wave irradiation by the reaction of 2-amino thiophenol... 相似文献
10.
The chemo-enzymatic synthesis of racemic and enantiopure (RS)- and (S)-enciprazine 1, a non-benzodiazepine anxiolytic drug, is described herein. The synthesis started from 1-(2-methoxyphenyl) piperazine 3, which was treated with 2-(chloromethyl) oxirane (RS)-4 using lithium bromide to afford a racemic alcohol, 1-chloro-3-(4-(2-methoxyphenyl) piperazin-1-yl) propan-2-ol (RS)-6 in 85% yield. Intermediate (S)-6 was synthesized from racemic alcohol (RS)-6 using Candida rugosa lipase (CRL) with vinyl acetate as the acyl donor. Various reaction parameters such as temperature, time, substrate, enzyme concentration, and the effect of the reaction medium on the conversion and enantiomeric excess for the transesterification of (RS)-6 by CRL were optimized. It was observed that 10 mM of (RS)-6, 50 mg/mL of CRL in 4.0 mL of toluene with vinyl acetate (5.4 mmol) as acyl donor at 30 °C gave good conversion (C = 49.4%) and enantiomeric excess (eeP = 98.4% and eeS = 96%) after 9 h of reaction. Compound (S)-6 is a key intermediate for the synthesis of enantiopure (S)-1. The (RS)- and (S)-enciprazine drug 1 was synthesized by treating (RS)- and (S)-6 with 3,4,5-trimethoxyphenol 5 using MeCN as a solvent and K2CO3 as a base. 相似文献