Synthesis,spectral investigation and development of tetrahedral copper(II) complexes as artificial metallonucleases and antimalarial agents

Seven new copper(II) complexes of type [Cu(A)(L)]?H₂O (A = sparfloxacin, ciprofloxacin, levofloxacin, gatifloxacin, pefloxacin, ofloxacin, norfloxacin; L = 5‐[(3‐chlorophenyl)diazenyl]‐4‐hydroxy‐1,3‐thiazole‐2(3H)‐thione) were synthesized and characterized using elemental and thermogravimetric analyses, and electronic, electron paramagnetic resonance (EPR), Fourier transform infrared and liquid chromatography–mass spectroscopies. Tetrahedral geometry around copper is assigned in all complexes using EPR and electronic spectral analyses. All complexes were investigated for their interaction with herring sperm DNA utilizing absorption titration (K_b = 1.27–3.13 × 10⁵ M^?1) and hydrodynamic volume measurement studies. The studies suggest the classical intercalative mode of DNA binding. The cleavage reaction on pUC19 DNA was monitored by agarose gel electrophoresis. The results indicate that the Cu(II) complexes can more effectively promote the cleavage of plasmid DNA. The superoxide dismutase mimic activity of the complexes was evaluated by nitroblue tetrazolium assay, and the complexes catalysed the dismutation of superoxide at pH = 7.8 with IC₅₀ values in the range 0.597–0.900 μM. The complexes were screened for their in vitro antibacterial activity against five pathogenic bacteria. All the complexes are good cytotoxic agents and show LC₅₀ values ranging from 5.559 to 11.912 µg ml^?1. All newly synthesized Cu(II) complexes were also evaluated for their in vitro antimalarial activity against Plasmodium falciparum strain (IC₅₀ = 0.62–2.0 µg ml^?1). Copyright © 2015 John Wiley & Sons, Ltd.     

Recent trends in optical data processing

Optical data processing is an advancing field which has received much attention in recent years. Optical techniques have already shown their applicability in target identification, advanced signal processing operations and advanced linear algebra operations. The potential capabilities of processing of data using photons instead of electrons as the carrier of information have established, beyond any doubt, that the optical techniques will be the next generation technology surpassing electronic techniques in some important areas such as air traffic control, missile guidance and remote sensing. Although great strides have been made in all the areas of optical data processing, the goal of high performance, high speed and very accurate all-optical computers would be realised only around the year 1995. The main difficulty is that the required materials for high resolution and fast spatial light modulators and optical interconnects are yet to be perfected. The present paper reviews the recent trends and the future prospects of optical data processing.     

Order Embeddings with Irrational Codomain: Debreu Properties of Real Subsets

The objective of this paper is to investigate the role of the set of irrational numbers as the codomain of order-preserving functions defined on topological totally preordered sets. We will show that although the set of irrational numbers does not satisfy the Debreu property it is still nonetheless true that any lower (respectively, upper) semicontinuous total preorder representable by a real-valued strictly isotone function (semicontinuous or not) also admits a representation by means of a lower (respectively, upper) semicontinuous strictly isotone function that takes values in the set of irrational numbers. These results are obtained by means of a direct construction. Moreover, they can be related to Cantor’s characterization of the real line to obtain much more general results on the semicontinuous Debreu properties of a wide family of subsets of the real line.      

Topological investigations of molar excess volumes of quinoline with alkanols

Excess volumes V ^E of binary liquid mixtures of quinoline with alkanols have been determined from densities at 30°C as a function of composition. The excess volumes are negative over the whole mole fraction range for all the mixtures and decrease with increasing length of alkanol (C₁–C₁₀). The V^E data have been analyzed in terms of an approach which uses graph theoretical connectivity parameters of the third degrees for two components. The analysis gives information regarding associated species in the pure state and in the mixture. It is suggested that, in the mixture state, no change occurs in the association of alkanols.     

Kinetics and hydrothermal transformation of gibbsite

The transformation of gibbsite have been studied under hydrothermal influence. Results of the X-ray diffraction analysis of the samples heated at different temperatures from 170°C to 265°C are also discussed in detail. The percentage of the boehmite phase formed, due to the transformation of the gibbsite, have been determined by comparing the intensity of the most strongest reflection of the boehmite phase with a fully transformed sample. The activation energy value calculated form X-ray diffractograms is almost comparable with the value calculated from main DTA endotherm of gibbsite.Es wurde die Umwandlung von Gibbsit unter hydrothermalem Einfluß untersucht. Weiterhin werden auch Ergebnisse der Röntgendiffraktionsanalyse an den bei verschiedenen Temperaturen zwischen 170°C und 265°C erhitzten Proben besprochen. Durch Vergleich der Intensität der stärksten Reflexion der Böhmitphase mit einer vollständig umgewandelten Probe wurde der prozentuelle Anteil der während der Umwandlung von Gibbsit gebildeten Böhmitphase bestimmt. Der Wert für die Aktivierungsenergie, berechnet aus den Röntgendiffraktogrammen ist annähernd vergleichbar mit dem aus der DTA von Gibbsit berechneten Wert.

---

RRL Contribution No. 2028.     

Magnetized cosmological model

The object of this paper is to investigate the behavior of the magnetic field in a cosmological model for perfect fluid distribution. The magnetic field is due to an electric current produced along thex axis. It is assumed that expansion () in the model is proportional to ₁ ¹ , the eigenvalue of the shear tensor _i ^j . The behavior of the model when the magnetic field tends to zero and other physical properties are also discussed.