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1.
A solid-phase reagent based on 1-(4-adamantyl-2-thiasolylazo)-2-naphthol adsorbed onto silica gel was prepared for Co(II) recovery and preconcentration prior to its sorption-spectroscopic detection. The immobilized reagent was applied to the determination of free cobalt ions in natural water. The solid-phase reagent and chemiluminescent method coupled with membrane filtration, gel-permeation and ion-exchange chromatography were applied to the study of the speciation of iron and cobalt in water from the Dnieper reservoirs and lakes of Kyiv City; their predominant forms were complexes of Fe(III) and Co(II) with dissolved organic matter and fulvic acids play a main role in their complexation. 相似文献
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Ohorodnik Yulia M. Alexander Sikalov A. Khomenko Dmytro M. Doroshchuk Roman O. Raspertova Ilona V. Shova Sergiu Babak Maria V. Lampeka Rostyslav D. 《Transition Metal Chemistry》2022,47(6):213-221
Transition Metal Chemistry - The structures of new p-cymene Ru(II) complexes with 2-(1-methyl-1H-1,2,4-triazol-3-yl)pyridine and 2-(1-methyl-1H-1,2,4-triazol-5-yl)pyridine were established based on... 相似文献
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Hülya Gizem Özkan Vanrajsinh Thakor Hong-Gui Xu Galyna Bila Prof. Dr. Rostyslav Bilyy Daria Bida Dr. Martin Böttcher Prof. Dr. Dimitrios Mougiakakos Dr. Rainer Tietze Prof. Dr. Andriy Mokhir 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(30):e202104420
Elevated levels of reactive oxygen species (ROS) and deficient mitochondria are two weak points of cancer cells. Their simultaneous targeting is a valid therapeutic strategy to design highly potent anticancer drugs. The remaining challenge is to limit the drug effects to cancer cells without affecting normal ones. We have previously developed three aminoferrocene (AF)-based derivatives, which are activated in the presence of elevated levels of ROS present in cancer cells with formation of electron-rich compounds able to generate ROS and reduce mitochondrial membrane potential (MMP). All of them exhibit important drawbacks including either low efficacy or high unspecific toxicity that prevents their application in vivo up to date. Herein we describe unusual AF-derivatives lacking these drawbacks. These compounds act via an alternative mechanism: they are chemically stable in the presence of ROS, generate mitochondrial ROS in cancer cells, but not normal cells and exhibit anticancer effect in vivo. 相似文献
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Aleksandra Dymek Jarosaw Widelski Krzysztof Kamil Wojtanowski Paulina Poszaj Rostyslav Zhuravchak Tomasz Mroczek 《Molecules (Basel, Switzerland)》2021,26(6)
Alkaloids of the Lycopodiaceae family are of great interest to researchers due to their numerous properties and wide applications in medicine. They play a very important role mainly due to their potent antioxidant, antidepressant effects and a reversible ability to inhibit acetylcholinesterase (AChE) enzyme activity. This property is of immense importance due to the growing problem of an increasing number of patients with neurodegenerative diseases in developed countries and a lack of effective and efficient treatment for them. Numerous studies have shown that Lycopodiaceae alkaloids are a rich source of AChE inhibitors. In the obtaining of new therapeutic phytochemicals from plant material, the extraction process and its efficiency is crucial. Therefore, the aim of this work was to optimize the conditions of modern PLE to obtain bioactive alkaloids from two Lycopodium species: L. clavatum L. and L. annotinum L. Five different solvents of different polarity were used for prepared plant extracts in order to compare the alkaloid content in and thereby effectiveness of the entire extraction. PLE parameters were used based on multiple studies conducted that gave the highest alkaloids recovery. Crude extracts were purified using solid-phase extraction (SPE) on Oasis HLB cartridge and examined by HPLC/ESI-QTOF–MS of the highly abundant alkaloids. To the best of our knowledge, this is the first time such high recoveries have been obtained for known Lycopodiaceae alkaloids. The best extraction results of alkaloid-lycopodine were detected in the dichloromethane extract from L. clavatum, where the yield exceeded 45%. The high recovery of annotinine above 40% presented in L. annotinum was noticed in dichloromethane and ethyl acetate extracts. Moreover, chromatograms were obtained with all isolated alkaloids and the best separation and quality of the bands in methanolic extracts. Interestingly, no alkaloid amounts were detected in cyclohexane extracts belonging to the non-polar solvent. These results could be helpful for understanding and optimizing the best conditions for isolating potent AChE inhibitors. 相似文献
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Micromorphic Homogenisation of a Porous Medium: Application to Size Effects and Quasi-Brittle Damage
The classical theory of continuum mechanics requires that distances over which gradients occur are much larger than the length scales of the microstructure. This requirement is violated if deformation localizes due to material softening which is why the predictions of classical damage models feature certain unrealistic aspects. In the present contribution, a micromorphic model for quasi-brittle damage, derived through homogenisation, is employed in FEM simulations to overcome this problem. (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
6.
Let G be a group and ?:H→G be a contracting homomorphism from a subgroup H<G of finite index. V. Nekrashevych (2005) [25] associated with the pair (G,?) the limit dynamical system (JG,s) and the limit G-space XG together with the covering ?g∈GT⋅g by the tile T. We develop the theory of self-similar measures m on these limit spaces. It is shown that (JG,s,m) is conjugated to the one-sided Bernoulli shift. Using sofic subshifts we prove that the tile T has integer measure and we give an algorithmic way to compute it. In addition we give an algorithm to find the measure of the intersection of tiles T∩(T⋅g) for g∈G. We present applications to the invariant measures for the rational functions on the Riemann sphere and to the evaluation of the Lebesgue measure of integral self-affine tiles. 相似文献
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Beata?A.?Zasońska Helena?Hlídková Eduard?Petrovsky Severyn?Myronovskij Tetyana?Nehrych Nazar?Negrych Mariya?Shorobura Volodymyr?Antonyuk Rostyslav?Stoika Yuriy?Kit Daniel?HorákEmail authorView authors OrcID profile 《Mikrochimica acta》2018,185(5):262
Monodisperse nonmagnetic macroporous poly(glycidyl methacrylate) (PGMA) microspheres were synthesized by multistep swelling polymerization of glycidyl methacrylate, ethylene dimethacrylate and 2-[(methoxycarbonyl)methoxy]ethyl methacrylate (MCMEMA). This was followed (a) by ammonolysis to modify the microspheres with amino groups, and (b) by incorporation of iron oxide (γ-Fe2O3) into the pores to render the particles magnetic. The resulting porous and magnetic microspheres were characterized by scanning and transmission electron microscopy (SEM and TEM), atomic absorption and Fourier transform infrared spectroscopy (AAS and FTIR), elemental analysis, vibrating magnetometry, mercury porosimetry and Brunauer-Emmett-Teller adsorption/desorption isotherms. The microspheres are meso- and macroporous, typically 5 μm in diameter, contain 0.9 mM · g?1 of amino groups and 14 wt.% of iron according to elemental analysis and AAS, respectively. The particles were conjugated to p46/Myo1C protein, a potential biomarker of autoimmune diseases, to isolate specific autoantibodies in the blood of patients suffering from multiple sclerosis (MS). The p46/Myo1C loaded microspheres are shown to enable the preconcentration of minute quantities of specific immunoglobulins prior to their quantification via SDS-PAGE. The immunoglobulin M (IgM) with affinity to Myo1C was detected in MS patients. 相似文献
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Viktor Reshetnikov Steffen Daum Dr. Christina Janko Weronika Karawacka Dr. Rainer Tietze Prof. Dr. Christoph Alexiou Dr. Solomiya Paryzhak Dr. Tetiana Dumych Prof. Dr. Rostyslav Bilyy Dr. Philipp Tripal Dr. Benjamin Schmid Dr. Ralf Palmisano Prof. Dr. Andriy Mokhir 《Angewandte Chemie (International ed. in English)》2018,57(37):11943-11946
Mitochondrial membrane potential is more negative in cancer cells than in normal cells, allowing cancer targeting by delocalized lipophilic cations (DLCs). However, as the difference is rather small, these drugs affect also normal cells. Now a concept of pro‐DLCs is proposed based on an N‐alkylaminoferrocene structure. These prodrugs are activated by the reaction with reactive oxygen species (ROS) forming ferrocenium‐based DLCs. Since ROS are overproduced in cancer, the high‐efficiency cancer‐cell‐specific targeting of mitochondria could be achieved as demonstrated by fluorescence microscopy in combination with two fluorogenic pro‐DLCs in vitro and in vivo. We prepared a conjugate of another pro‐DLC with a clinically approved drug carboplatin and confirmed that its accumulation in mitochondria was higher than that of the free drug. This was reflected in the substantially higher anticancer effect of the conjugate. 相似文献
10.
Rostyslav Kozhan 《Communications in Mathematical Physics》2014,327(3):921-950
We find a necessary and sufficient condition for a Herglotz function m to be the Borel transform of the spectral measure of an exponential decaying perturbation of a periodic Jacobi matrix. The condition is in terms of meromorphic continuation of m to a natural Riemann surface and the structure of its zeros and poles. The analogous result is also established for the Borel transform of the spectral measure of eventually periodic Jacobi matrices. This paper generalizes the corresponding result from the author’s (Constr Approx 36(2):267–309, 2012) for exponential perturbations of the free Jacobi matrix. 相似文献